原创力文档Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4 英文论文文献.docVIP
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Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4 英文论文文献
Aranetal.BMCBiochemistry2011,12:19
/1471-2091/12/19
RESEARCH ARTICLE
OpenAccess
TyrosinephosphorylationofMunc18conresidue
521abrogatesbindingtoSyntaxin4
VeronicaAran1,2,NiaJBryant1* andGwynWGould1*
Abstract
Background:InsulinstimulatesexocytosisofGLUT4fromanintracellularstoretothecellsurfaceoffatandmuscle
cells.FusionofGLUT4-containingvesicleswiththeplasmamembranerequirestheSNAREproteinsSyntaxin4,
VAMP2andtheregulatorySec1/Munc18protein,Munc18c.Syntaxin4andMunc18cformacomplexthatis
disrupteduponinsulintreatmentofadipocytes.Munc18cistyrosinephosphorylatedinresponsetoinsulininthese
cells.He
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