原创力文档Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events 英文论文文献.docVIP
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Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events 英文论文文献
Kimetal.BMCCancer2011,11:528
/1471-2407/11/528
RESEARCH ARTICLE
OpenAccess
Tyrosinekinasechromosomaltranslocations
mediatedistinctandoverlappinggeneregulation
events
HaniKim1,3,LisaCGillis1,2,JordanDJarvis1,2,StuartYang3,KaiHuang1,SandyDer3andDwayneLBarber1,2,3*
Abstract
Background:Leukemiaisaheterogeneousdiseasecommonlyassociatedwithrecurrentchromosomal
translocationsthatinvolvetyrosinekinasesincludingBCR-ABL,TEL-PDGFRBandTEL-JAK2.Moststudiesonthe
activatedtyrosinekinaseshavefocusedonproximalsignalingevents,butlittleisknownaboutgenetranscription
regulatedbythesefusions.
Methods:Oligonucleo
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