Vascular stem cells in diabetic complications evidence for a role in the pathogenesis and the therapeutic promise 英文论文文献.docVIP
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Vascular stem cells in diabetic complications evidence for a role in the pathogenesis and the therapeutic promise 英文论文文献
KeatsandKhanCardiovascularDiabetology2012,11:37
/content/11/1/37
CARDIO
VASCULAR
DIABETOLOGY
REVIEW
OpenAccess
Vascularstemcellsindiabeticcomplications:
evidenceforaroleinthepathogenesisandthe
therapeuticpromise
EmilyCKeats1andZiaAKhan1,2,3*
Abstract
Longstandingdiabetesleadstostructuralandfunctionalalterationsinboththemicro-andthemacro-vasculature.
Vascularendothelialcells(ECs)aretheprimarytargetofthehyperglycemia-inducedadverseeffects.Vascularstem
cellsthatgiverisetoendothelialprogenitorcells(EPCs)andmesenchymalprogenitorcells(MPCs)representan
attractivetargetforcelltherapyfordiabeticpati
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