中枢神经系统常见肿瘤分子病理学及靶向治疗.pdfVIP

1106 . 中国现代神经疾病杂志2014 年 12 月第 14 卷第 12 期 Chin J Contemp Neuro1 Neurosurg , December 2014 , Vo l. 14, No. 12 ·综述· 中枢神经系统常见肿瘤分子病理学及靶向治疗 杨菲朴月善卢德宏 [摘要] 中枢神经系统肿瘤采用传统治疗方法难以治愈，由于传统化疗药物缺乏特异性，在抗肿瘤 的同时，对正常组织和器官也产生毒性作用。因此，针对中枢神经系统肿瘤细胞内分子通路特异性靶向 治疗成为近年研究的热点。本文拟从细胞内关键责任信号转导通路及基因突变位点的角度分别介绍髓 母细胞瘤、少突胶质细胞肿瘤和胶质母细胞瘤分子生物学特征及其与肿瘤预后的关系，以及肿瘤把向治 疗现状及进展，为中枢神经系统肿瘤的个体化治疗提供一些新的信息。 [关键词] 中枢神经系统肿瘤; 信号传导: 综述 Molecular patbology and targeted tberapy of common tumors in central nervous system YANG Fei , PIAO Yue-shan , LU Oe-hong Department 01 Pathology, Xuanwu Hospitα/， Cα:pitα1 Medical University, Beijing 100053, Chinα Corresponding αuthor: LU De-hong (Emαil: xwludehong@163.comj [Abstractl It is difficult to cure central nervous system tumors using traditional method , due to chemotherapy drugs lack of specificity. They kill the tumor cells , and damage normal tissues and organs at the same time. The latest hotspot 阳 targeted therapy on the specific molecules in the molecular pathway of central nervous system tumor cells. This review introduces the relationship between rnolecularly biological characteristics of medulloblastoma , oligodendrocytoma , glioblastoma and the prognosis in the view of critical intracellular pathway and genetic mutation. Furthermore , it reviews the current situation and progress of targeted therapy of tumors. As a consequence , it offers some new information for the individualized therapy of central nervous system tumors. [Key wordsl Central nervous system neoplasms; Signal transduction; Review This study was supported by Capital Medical Science Development Foundation (No. 2014-2-2013). 随着中枢神经系统肿瘤组织发生学、细胞生物 胚胎性神经上皮组织肿瘤，类似于颅内其他部位的 学和分子生物学研究的不断深入，中枢神经系统肿 原始