中药复方活血通对糖尿病大鼠肾组织晚期糖基化终产物影响的研究.docVIP

中药复方活血通对糖尿病大鼠肾组织晚期糖基化终产物影响的研究 　　【摘要】 目的 观察中药复方活血通对糖尿病大鼠晚期糖基化终产物(AGEs)的影响,探讨中药复方活血通防治糖尿病慢性并发症的作用机制。方法 采用链脲佐菌素糖尿病大鼠模型,随机分为预防组和治疗组,给予中药复方活血通灌胃,并以氨基胍作为对照,治疗12周,观察中药复方活血通对糖尿病大鼠血糖和肾组织AGEs的影响。结果 中药复方活血通预防组和治疗组血糖、中药复方活血通预防组、治疗组和氨基胍组肾组织AGEs均较模型组为低(P0.01);氨基胍组血糖高于中药复方活血通预防组(P0.05),与模型组比较,差异也有显著性(P0.05)。结论 中药复方活血通可能通过降低血糖,抑制终末期糖基化终产物在肾皮质中的形成,延缓糖尿病慢性并发症的进一步发展。 　　【关键词】 中药;活血通;糖尿病并发症;晚期糖基化终产物 　　文章编号:1003-1383(2009)05-0520-03 　　中图分类号:R 587.2文献标识码:A 　　doi:10.3969/j.issn.1003-1383.2009.05.004 　　Effects of hexue Composita on advanced glycation and products in kidneys of diabetic rats [HJ1*2][HJ] 　　XIONG Biane,LI Pu,LIU Ying, DENG Zuguo 　　(Department of Medicament,The peoples Hospital of Qiannan Autonomous profecturefor Buyi and Miao Nationalities,Duyun 558000 China) 　　【Abstract】 Objective To investigate the effects of activating blood and resolving stasis hexue Composita(HXC) on advanced glycation end products(AGES) in kidneys of diabetic rats. 　　Methods STZ induced diabetic rats were randomized to HXC prevention group and HXC treatment group. The levels of blood glucose and AGEs in kidneys of the animals were checked after 12 weeks′treatment and compared with that of aminoguanidine (AG) treatment group.Results Blood glucose level in the HXC prevention andt reatment group,and AGEs in kidneys of the HXC prevention group and the AG group were lower than those of the non treated group (P0.01).Blood glucose level in the AG group was higher than that in the HXC prevention group(P0.05),but was significantly different from that in the nontreated group (P0.05).Con 　　clusion HXC might delay the development of diabetic complications by decreasing blood glucose and inhibiting AGEs formation in kidneys of STZ induced diabetic rats. 　　【Key words】 Traditional Chinese Medicine;hexue Composita;diabetic complications;advanced glycation end products 　　 　　有研究表明,糖尿病长期高血糖可引起体内蛋白糖化,大量蛋白非酶糖化产物转化为不可逆的糖基化终产物(AGEs)。AGEs的蓄积和糖尿病各种并发症的发生有密切 　　关系[1]。因此,抑制AGEs的生成对预防糖尿病慢性并发症的发生、发展有重要意义。我们观察了中药复方活