小檗碱及其衍生物抑菌作用研究进展_钟慈平.pdfVIP

2013, Vol.34, No.07 321 1 2 1 1 1,* (1. 400716 2. 400067) Research Progress in Antimicrobial Effects of Berberine and Its Derivatives 1 2 1 1 1,* ZHONG Ci-ping QIAN Yu SHU Chang SUO Hua-yi LI Lin (1. College of Food Science, Southwest University, Chongqing 400716, China 2. Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China) Abstract Berberine is an isoquinoline alkaloid extracted from Chinese herb such as Coptidis rhizome. It has a variety of biological activities, and revealed a wide spectrum of clinical applications. On the other hand, due to its low bioavailability, its functional characteristic studies were limited to medical applications. Therefore, by chemical modification or transformation of chemical structure of berberine, a series of derivatives could improve its bacteriostasis. In this paper, the synthesis, inhibitory effect and mechanism progress of berberine and its derivatives could be used as preservatives or mixed with chitosan coating on fruits and vegetables for disease-preventing and fresh-keeping. In order to provide certain references for berberine, the preservative effects of berberine derivatives on preservative effect in foods. Key words berberine berberine derivatives antibacterial fresh-keeping TS201.6 A 1002-6630(2013)07-0321-05 (berberine) 11 [1] 4 5 O 3 6