干细胞移植治疗视网膜变性疾病面临的挑战和前景_阴正勤2013.pdfVIP

35 15 第 卷第 期 第 三 军 医 大 学 学 报 Vol． 35 ，No． 15 20 13 8 15 J Third Mil Med Univ Aug． 15 20 13 154 1 年 月 日 文章编号:1000-5404 (20 13)15-154 1-04 专家述评 干细胞移植治疗视网膜变性疾病面临的挑战和前景 阴正勤 (400038 ， ) 重庆 第三军医大学西南医院全军眼科中心 ［ ］ ; ; 关键词 视网膜变性 干细胞治疗 转化医学 ［ ］ R774 ． 13 ［ ］ A 中图法分类号 文献标志码 Translation of stem-cell-based therapies for retinal degeneration Yin Zhengqin (Department of Ophthalmology ，Southwest Hospital ，Third Military Medical University ，Chongqing ，400038 ，China) ［Abstract ］ Present therapies for retinal degenerative diseases are limited in their efficacy． Consequently ， the development of novel neuroprotective and neuroregenerative treatments is a top priority． Stem cells hold great promise for regenerative medicine ，and recently many efforts have been devoted to find suitable candidates for retinal transplants． A variety of stem-cell-based approaches are being advanced to replace impaired retinal cells and / or to slow the disease processes by providing neuroprotective factors ，with the ultimate aim of long- term improvement in visual function． Furthermore ，clinical trials are in the early stages ，and data on safety and efficacy are widely anticipated． We discussed here the challenges and potential of stem-cell-based therapies in treatment of retinal blindness． ［Key words ］ retinal degeneration ;stem cell therapy ;translational medicine Supported by the National Key Basic Research Program (973 Program ，20 13CB967000)． Corresponding author ，Yin Zhengqin ，Tel :86-23-6875440 1，E-mail : yzhengqin@ 163 ． com