S100B对新生儿缺氧缺血性脑病或脑损伤的诊断.pdfVIP

中国医药导刊 1151 2013年 第 15 卷 第 7 期（总第117期） S100B对新生儿缺氧缺血性脑病或脑损伤的诊断 丁国芳 (广东省深圳市宝安区松岗人民医院儿科,深圳 518105) 【摘要】目的:观察S100B在新生儿缺氧缺血性脑病或脑损伤(HIE)患儿血液中变化,并分析其在诊断中的作用。方法:选取我院缺 氧缺血性脑病或脑损伤患儿48例作为HIE组,根据其严重程度分为轻度、中度、重度HIE组,另选取同期正常新生儿25例作为对照 组,对比观察各种S100B水平变化情况。结果:HIE组患儿急性期S100B含量水平明显高于对照组,差异有统计学意义(P0.05);恢复期 S100B含量水平降至与对照组相近(P0.05) 。结论:HIE患儿的血清S100B蛋白含量明显高于正常新生儿,而病情得到控制恢复后该 蛋白含量又降至正常水平,可以认为血清S100B检测对HIE患儿具有一定临床诊断意义。 S100B蛋白;新生儿;缺氧缺血性脑病(HIE);脑损伤;临床诊断 【关键词】 R722.1 A 1009-0959(2013)07-1151-02 【中图分类号】 【文献标识码】 【文章编号】 S100B Diagnosis of Neonatal Hypoxic Ischemic Encephalopathy and Brain Injury Ding Guo-fang (Guangdong Province Shenzhen city Baoan District Songgang peoples Hospital department of paediatrics, Shenzhen 518105, China) 【 】 To observe the effect of S100B in neonates with hypoxic ischemic encephalopathy or brain damage(HIE) ABSTRACT Objective: in children with blood, and analyses its role in the diagnosis of. Methods: In our hospital with hypoxic ischemic encephalopathy or brain injury were 48 cases as HIE group, according to the severity and divided into mild, moderate, severe HIE group, another 25 normal newborns were selected as control group. Results: The S100B levels of HIE patients in acute stage was significantly higher than the control group, the difference was statistically significant (P0.05); recovery S100B content reduced to the level similar to that in the control group(P0.05). Conclusion: The serum S100B protein content in HIE were significantly higher than those in normal