丙泊酚与舒芬太尼相互作用的药效学关系.pdf

·840· ．临床研究· 丙泊酚与舒芬太尼相互作用的药效学关系 谢国柱王荣宁卞丽玉钱涛顾政孙灿林 【摘要】目的观察临床浓度范围内丙泊酚与舒芬太尼相互作用的药效学变化。方法选择 ASA I或Ⅱ级、拟在全身麻醉下择期行腹部手术患者36例，应用靶控输注系统给予逐渐增加的丙泊 酚和舒芬太尼浓度，第一阶段随机给予三个浓度梯度丙泊酚或舒芬太尼，第二阶段及第三阶段同时 给予随机浓度组合的丙泊酚与舒芬太尼，浓度达稳态后记录脑电双频指数(BIS)及血压。浓度效应 数据用于计算相互作用指数(a)。结果BIS与血压变化的直线方程显示，丙泊酚与舒芬太尼两者相 互作用指数a与零比较差异无统计学意义。结论临床浓度范围内丙泊酚与舒芬太尼联合应用药 效学指标仅表现为简单的相加作用，因此两药联合应用不必减少各自用量。 【关键词】 丙泊酚；舒芬太尼；药效学；药物相互作用 and interactionbetween sufentanilxlEGuo-zhu．WANG Pharmaeodymmic propofol Rong-ning· a1．Department 225300， BlAN“一yu，et ofAnesthesiology，TaizhouPeoplesHospital．Taizhou Jiangsu，China Toobservethe interactionbetween and [Abstract]Objective pharmaeodynamic propof01 sufentanilin doses．Methodssix withASA status clinically—used Thirtypatients physieal I／lI selectiveabdominal were concentrationof studied．Staircase-increasing undergoing surgeries profiles andsufentanilwere the infusionofthetwo propof01 produced target-controlled drugs．Three through differentconcentrationsofthetwo were atthefirst ofinduction，andthen drugs randomlygiven stage variablecombinationsofboth indifferentconcentrationswereusedatthesecondandthird drugs ofinduction．Ateachconcentrationofthe index(BIS)andblood stages plateau drug，bispectral werereeored．Concentration-effectwereusedtOdeterminetheinteractionindex pressure relationships ofboth ThelinearfunctionsofbothBISandblood showedtherewasno drugs．Resulb pressure statistical both basal of betweenthevalueofaof and ze