儿童细菌性脓毒症的抗生素应用.pdf

·专题讨论· 儿童细菌性脓毒症的抗生素应用 桑田 王颖 【摘要】 脓毒症是与感染相关的全身炎症反应综合征，甲．期应用有效抗生素和积极复苏是救治 关键，其中早期及TF确的静脉抗牛素应用是严重脓毒症／脓毒性休克患者舛i存的独立预测因素。儿童的 年龄及免疫状态对病原芮谱有较强的提示作用，初始经验治疗应选用能覆盖所有呵能病原的抗生素，并 且在町疑感染源部位有较高的渗透浓度，在得到病原学结果后尽快降为目标治疗。 【关键词】脓毒症；抗感染治疗；儿蕈 Antibioticof SANG Universi一 pediatric Tian，WANG therapy sepsis Ying．Department∥’Pediatrics，Peking 略Ftrst 100034。China． Hospital，Beijing author：WANG Corresponding Ying(E-mail：bywangying@sina．com) is associatedwith 【Abstract】Sepsissystemicinflammatorysyndrome recog— response infection．Early nitionof or severe resuscitationandtheimmediateinitiationofeffec— sepsissepticshock，earlyhemodynamic the tireintravenousanti—infectiveare cornerstonesinthe of with in— therapy managementpatientssepsis．The fectious associatedwith in withthe andimmune microorganisms sepsispediatricpatientsvary patient’Sage status．Initial antimicrobialshouldincludeone more that all or have empirical therapy drugs activityagainst and that in concentrations likelypathogens intothe sourceof penetrateadequate presumed sepsis．Empirically shouldbede—escalatedtothemost as as is soonthe therapy appropriatesingletherapy susceptibilityagent known． words】 【Key Sepsis；Antibiotictherapy；Children 菌和沙雷菌属。在美国和发达国家，由于联合流 脓毒症(se