Analysis of Cocaine and Crack Cocaine via Thin Layer Chromatography Coupled to Easy Ambient Sonic-Spray Ionization Mass Spectrometry英文文献资料.docVIP

American Journal of Analytical Chemistry, 2011, 2, 658-664 doi:10.4236/ajac.2011.26075 Published Online October 2011 (http://www.SciRP.org/journal/ajac) Analysis of Cocaine and Crack Cocaine via Thin Layer Chromatography Coupled to Easy Ambient Sonic-Spray Ionization Mass Spectrometry Bruno D. Sabino Denise B. Rocha Pinto , Wanderson Rom?o , Morena L. Sodré , Deleon N. Correa , 1,2* 3 1 3 1 1 3 , Fábio O. M. Alonso , Marcos N. Eberlin 1 Institute of Criminalistic Carlos éboli, Rio de Janeiro, Brazil, 2 National Institute of Metrology, Standardization and Industrial Quality, Av. N. Sra. das Gra?as, Duque de Caxias, Brasil ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas, Campinas, Brazil * E-mail: brsabino@.br Received June 20, 2011; revised July 27, 2011; accepted August 3, 2011 3 Abstract Cocaine and crack cocaine are usually seized with a great diversity of adulterants, such as benzocaine, lido- caine, caffeine, and procaine. The forensic identification of cocaine in these drug mixtures is normally per- formed using colorimetric testing kits, but these tests may suffer from interferences providing false-positive or false-negatives. In this work, we describe the use of thin layer chromatography coupled to easy sonic-spray ambient ionization mass spectrometry (TLC/EASI-MS) for rapid and secure analysis of cocaine and crack cocaine. Fifteen cocaine samples were analyzed, and all of them revealed positive TLC/EASI-MS results for cocaine, but other drugs and adulterants were also detected such as lidocaine, caffeine, benzocaine, lactose, benzoylecgonine, and ecgonidine. False positives and false negatives, as judged by the TLC Rf val- ues, were iden