Analysis of IgE turnover in non-sensitized and sensitized rats英文文献资料.docVIP

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Analysis of IgE turnover in non-sensitized and sensitized rats英文文献资料.doc

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Analysis of IgE turnover in non-sensitized and sensitized rats英文文献资料

Short Communication Mediators of Inflammation, 10, 217–221 (2001) Background:Althoughthelevelsofimmunoglobulin E (IgE) in the circulating blood are often elevated in patients with allergic diseases, such levels cannot always be considered as pathognomonic signs of allergy. The induction of allergic reactions in the tissue was inferred to be related to the amount of IgE passing through the vascular wall. Analysis of IgE turnover in non-sensitized and sensitized rats Kazuhiko Hanashiro1,CA, Yoshihiro Tokeshi Toshiyuki Nakasone1,2, Masanori Sunagawa and Tadayoshi Kosugi 1 , 1 , Aims: We attempted to clarify which compartment, theintravascularorextravascular,playsanimportant role in the regulation of the turnover of rat IgE. Methods: The level of DNP-specific rat IgE in the serum was estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of IgE was analyzed from its pharmacokinetic parameters. Results: The transfer rate constants from the central to tissue compartment (Kct) were larger than those Mariko Nakamura 1 1 1 1st Department of Physiology and Department of 2 Oral and Maxillofacial Surgery, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903–0215, Japan from the tissue to central compartment (K ) irrespec- tc tive of the sensitized state. The value of the distribu- tion volume of the tissue compartment (V) was larger t CA Corresponding Author Tel: +81 98 895 1108 Fax: +81 98 895 1402 E-mail: tkosugi@med.u-ryukyu.ac.jp than that of the distribution volume of the central compartment (Vc) irrespective of the sensitized state. Conclusions: These findings suggest that the short half-life of rat IgE in the circulation could be attribut- able to the distribution of IgE from the intravascular to the extravascular compartment. Key words: Rodent, Allergy, Antibodies, IgE turnover, In vivo animal models Introduction and the catabolism of IgE is related to the interaction of IgE with Fc? receptor-bearing cells