Antenatal Sonographic Diagnosis of A Case of Alobar Holoprosencephaly A Case Report英文文献资料.docVIP

International Journal of Clinical Medicine, 2012, 3, 431-432 1 /10.4236/ijcm.2012.35080 Published Online September 2012 (http://www.SciRP.org/journal/ijcm) Antenatal Sonographic Diagnosis of a Case of Alobar Holoprosencephaly: A Case Report Rizwan Ahmad Khan , Manjari Thapa , Shagufta Wahab 1 2 2* 1 Division of Pediatric Sugery, Department of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, India; of Radiodiagnosis, JN Medical College, Aligarh Muslim University, Aligarh, India. 2 Department Email: drshaguftawahab@ * Received May 2 , 2012; revised June 6 , 2012; accepted July 19 , 2012 nd th th ABSTRACT Holoprosencephaly is a rare congenital brain malformation resulting from failure of diverticulation and cleavage of primitive prosencephalon which occurs at 4th - 8th week of gestation and is usually associated with multiple midline facial anomalies. Herein we report an antenatal case of such patient. Patient was evaluated and because of the magni- tude of the problem induction was done which led to a still born baby. Keywords: Holoprosencephaly; Alobar; Antenatal Detection; Developing Countries; Prognosis 1. Introduction natal sonographic findings a diagnosis of alobar holo- prosencephaly was made. Preterm induction of vaginal delivery resulted in a stillborn fetus. Examination of the fetus demonstrated only proptosis but no gross facial anomaly. Brain morphology could not be assessed due to autolysis. Chromosomal analysis disclosed a trisomy 13 karyotype. Patient was investigated as per the guidelines set by the Ethics committee of our hospital. Holoprosencephaly is a rare congenital brain malforma- tion resulting from failure of diverticulation and cleavage of primitive prosencephalon which oc