Antiviral effects of a synthetic Aluminium-Magnesium Silicate, on Avian Influenza Virus英文文献资料.docVIP

Vol.4, No.7, 429-432 (2012) Health /10.4236/health.2012.47067 Antiviral effects of a synthetic Aluminium-Magnesium Silicate, on Avian Influenza Virus Maduike C. O. Ezeibe Omadi Ijabo 1 *, Antony N. Egbuji 2 , Obianuju N. Okoroafor 1 , James I. Eze 1 , 1 , Augustine A. Ngene 1 1 Mary E. Sanda , Ijeoma J. Mbuko 1 , Ikechukwu C. Eze , Joseph A. C. Ugonabo , 3 3 1 * 2 3 Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria; Corresponding Author: Ezeibe,MaduikeC.O.maduikeezeibe@ Viral Research Laboratory, National Veterinary Research Institute, Vom, Nigeria Department of Microbiology, University of Nigeria, Nsukka, Nigeria Received 6 January 2012; revised 24 February 2012; accepted 13 April 2012 ABSTRACT of their matrix proteins [1]. Avian Influenza Viruses are Influenza A viruses [2]. The Influenza A viruses are sub- divided, serologically, into sixteen H and nine NA sub- types. All these subtypes infect avian species. However, they coexist with water fowls, sea birds and other wild birds which are their natural hosts, in perfect harmoney [2]. Disease outbreaks occur in domestic birds when they come in contact with these wild birds or with infected pigs [2]. The wild birds which are carriers of Influenza viruses shed them in their secretions and excretions. So, domestic birds can also get infected if they contact secretions or excretions of infected wild birds or with fomites [3]. Avian Influenza Viruses cause two main forms of dis- ease, distinguished by low or high virulence, in domestic poultry.The low pathogenic form causes only ruffled fea- thers and drop in egg production while the Highly Pa- thogenic Avian Influenza Viruses (HPAIV) spread rapidly between flocks, affect many organs of infected birds and lead to high mortality within 48 hours [3]. Genetic characterizat