Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals英文文献资料.docVIP

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Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals英文文献资料.doc

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Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals英文文献资料

SAGE-HindawiAccesstoResearch MalariaResearchandTreatment Volume2011,ArticleID703730,5pages doi:10.4061/2011/703730 ReviewArticle Artemether-LumefantrineCombinationTherapyfor TreatmentofUncomplicatedMalaria:ThePotentialfor ComplexInteractionswithAntiretroviralDrugsin HIV-InfectedIndividuals PaulineByakika-Kibwika,1,2MohammedLamorde,1,2HarrietMayanja-Kizza,1 SayeKhoo, 3ConceptaMerry,1,2andJean-PierreVangeertruyden4 1 InfectiousDiseasesInstituteandInfectiousDiseasesNetworkforTreatmentandResearchinAfrica(INTERACT), MakerereUniversityCollegeofHealthSciences,P.O.Box7061,Kampala,Uganda 2 3 4 DepartmentofPharmacologyandTherapeutics,TrinityCollegeDublin2,Ireland DepartmentofPharmacologyandTherapeutics,UniversityofLiverpool,LiverpoolL693BX,UK InternationalHealth,EpidemiologyenSocialMedicine,UniversiteitAntwerpen,Universiteitsplein1,2610Antwerp,Belgium CorrespondenceshouldbeaddressedtoPaulineByakika-Kibwika,pbyakika@ Received14December2010;Accepted14February2011 AcademicEditor:NeenaValecha Copyright?2011PaulineByakika-Kibwikaetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. TreatmentofmalariainHIV-infectedindividualsreceivingantiretroviraltherapy(ART)posessigni?cantchallenges.Artemether- lumefantrine(AL)is oneof theartemisisnin-basedcombinationtherapies recommended fortreatment of malaria.The drug combinationishighlye?caciousagainstsensitiveandmultidrugresistantfalciparummalaria.Bothartemetherandlumefantrine aremetabolizedbyhepaticcytochromeP450(CYP450)enzymeswhichmetabolizetheproteaseinhibitors(PIs)andnonnucleoside reversetranscriptaseinhibitors(NNRTIs)usedforHIVtreatment.CoadministrationofNNRTIsandPIswithALcouldpotentially causecomplexpharmacokineticdruginteractions.NNRTIbyinducingCYP4503A4enzymeandPIsbyinhibitingCYP4503A4 enzymescouldin?uencebothartemetherandlumefantrineconcentrationsandtheiractivemetabolitesdihydroa