Arterial Imaging in Digital Gangrenes Associated with Scleroderma-Spectrum Disorders英文文献资料.docVIP

Open Journal of Rheumatology and Autoimmune Diseases, 2012, 2, 21-25 21 /10.4236/ojra.2012.22005 Published Online May 2012 (http://www.SciRP.org/journal/ojra) Arterial Imaging in Digital Gangrenes Associated with Scleroderma-Spectrum Disorders* Naoko Nagata Mamori Tani 1 , Atsushi Tanemura 1# , Hiroki Higashihara 2 , Yorihisa Kotobuki 1 , Hiroyuki Murota 1 , 1 , Ken Igawa , Ichiro Katayama 1 1 1 2 Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Radiology, Osaka Uni- versity Graduate School of Medicine, Osaka, Japan. # Email: tanemura@derma.med.osaka-u.ac.jp Received January 10 , 2012; revised February 13 , 2012; accepted February 20 , 2012 th th th ABSTRACT Objectives: Digital refractory gangrene is rarely found in collagen diseases, including systemic sclerosis and is possibly caused by similar underlying vascular damage in peripheral arterial disease (PAD) such as arteriosclerosis obliterans (ASO) and/or thromboangiitis obliterans (TAO) by unclarified mechanisms other than vasculitis and thrombosis. This study evaluated the radiological imaging in patients with digital gangrene associated with collagen disease and com- pared the images with those of PAD based on the results of laboratory and histopathological examinations. Methods: Angiography, MR angiography and/or CT angiography were performed on 6 patients with refractory gangrene or ex- tensive ulcers accompanied by scleroderma-spectrum disorders; 3 with diffuse systemic sclerosis, 1 with limited sys- temic sclerosis, 1 with overlap syndrome and 1 with Sj?gren’s syndrome. Results: Although the vascular alterations in collagen diseases were similar to those in PAD, the abnormal image findings (occlusion or stenosis of the arteries w