Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest英文文献资料.docVIP

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Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest英文文献资料.doc

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Assessment of Procalcitonin to Predict Outcome in Hypothermia-Treated Patients after Cardiac Arrest英文文献资料

HindawiPublishingCorporation CriticalCareResearchandPractice Volume2011,ArticleID631062,7pages doi:10.1155/2011/631062 ClinicalStudy AssessmentofProcalcitonintoPredict OutcomeinHypothermia-TreatedPatientsafter CardiacArrest PascalStammet, 1 YvanDevaux, 1 2 FranciscoAzuaje, ChristopheWerer, 2 1 andMartinMax 1 ChristianeLorang, GeorgesGilson, 3 1 2 3 DepartmentofAnaesthesiaandIntensiveCare,LuxembourgMedicalCentre(CHL),1210Luxembourg,Luxembourg LaboratoryofCardiovascularResearch,PublicResearchCentreforHealth(CRP-Sante),1150Luxembourg,Luxembourg DepartmentofClinicalBiology,LuxembourgMedicalCentre(CHL),1210Luxembourg,Luxembourg CorrespondenceshouldbeaddressedtoPascalStammet,stammet.pascal@chl.lu Received25May2011;Revised14July2011;Accepted10August2011 AcademicEditor:RomergrykoG.Geocadin Copyright?2011PascalStammetetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objective.Determinethepotentialofprocalcitonin(PCT)topredictneurologicaloutcomeafterhypothermiatreatmentfollowing cardiacarrest.Methods.Retrospectiveanalysisofpatientdataovera2-yearperiod.Mortalityandneurologicaloutcomeofsurvivors were determined 6 months after cardiac arrest using the Cerebral Performance Category (CPC) score. Results. Data from 53 consecutivepatientswereanalyzed.Medianagewas63(54–71)and79%weremale.Twenty-sevenpatientshadgoodoutcome (CPC≤2) whereas 26 had severe neurological sequelae or died (CPC 3–5). At 48h, after regaining normothermia, PCT was signi?cantly higher in patients with bad outcome compared to those with good outcome: 3.38 (1.10–24.48) versus 0.28 (0– 0.75)ng/mL(P0.001).PCTvaluescorrelatedwithbadneurologicaloutcome(r =0.54,P =0.00004)andpredictedoutcome withanareaunderthecurveof0.84(95%CI0.73–0.96).Acuto?pointof1ng/mLprovidedasensitivityof85%andaspeci?city of81%.AboveaPCTlevelof16ng/mL,nopatientregain