Atomic Radiations in the Decay of Medical Radioisotopes A Physics Perspective英文文献资料.docVIP

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Atomic Radiations in the Decay of Medical Radioisotopes A Physics Perspective英文文献资料.doc

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Atomic Radiations in the Decay of Medical Radioisotopes A Physics Perspective英文文献资料

HindawiPublishingCorporation ComputationalandMathematicalMethodsinMedicine Volume2012,ArticleID651475,14pages doi:10.1155/2012/651475 ResearchArticle AtomicRadiationsintheDecayofMedicalRadioisotopes: APhysicsPerspective B.Q.Lee,T.Kib′edi,A.E.Stuchbery,andK.A.Robertson DepartmentofNuclearPhysics,ResearchSchoolofPhysicsandEngineering,TheAustralianNationalUniversity,Canberra, ACT0200,Australia CorrespondenceshouldbeaddressedtoT.Kib′edi,tibor.kibedi@.au Received21March2012;Revised17May2012;Accepted17May2012 AcademicEditor:EvaBezak Copyright?2012B.Q.Leeetal. This is an open access article distributed under the Creative Commons Attribution License, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Augerelectronsemittedinnucleardecayo?erauniquetooltotreatcancercellsatthescaleofaDNAmolecule.Overthelastforty yearsmanyaspectsofthispromisingresearchgoalhavebeenexplored,howeveritisstillnotinthephaseofseriousclinicaltrials. Inthispaper,wereviewthephysicalprocessesofAugeremissioninnucleardecayandpresentanewmodelbeingdevelopedto evaluatetheenergyspectrumofAugerelectrons,andhenceovercomethelimitationsofexistingcomputations. 1.Introduction the vacancy will be ?lled by an electron from the outer shells and the excess energy will be released as an X-ray photon,orbytheemissionofanAugerelectron.Referred toasatomicradiations,X-rayandAugerelectronemission are competing processes. The atomic transition rates, and whetherX-rayorAugeremissionisdominant,dependonthe atomicnumber,theelectronshellsinvolved,andtheelectron con?gurationoftheatom.Thefullrelaxationoftheinner- shell vacancy is a multistep process, resulting in a cascade ofatomicradiations.TheenergyofemittedX-raysand/or Augerelectronsdependsontheatomicnumber,theelectron shellsandelectroncon?gurationinvolved,andistypicallyin therangefromafeweVto100keV.Duetotheirshortrange (nmtoμm),Augerelectronswithrelativelylowenergiescan haveamuchhigherLET.Forexample,forelectronenergies bel