Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs英文文献资料.docVIP

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Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs英文文献资料.doc

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Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs英文文献资料

HindawiPublishingCorporation JournalofTransplantation Volume2011,ArticleID928759,9pages doi:10.1155/2011/928759 ResearchArticle AttemptedDepletionofPassengerLeukocytesby IrradiationinPigs Hao-ChihTai,1,2XiaochengZhu, 1 YihJyhLin, HidetakaHara, MohamedEzzelarab, 3 1 1 1 MichaelEpperley, 3 MubinaA.Quader, andDavidK.C.Cooper 1 1 2 3 ThomasE.StarzlTransplantationInstitute,UniversityofPittsburghMedicalCenter,Pittsburgh,PA15261,USA DepartmentofSurgery,NationalTaiwanUniversityHospitalandCollegeofMedicine,Taipei100,Taiwan DepartmentofRadiationOncology,UniversityofPittsburghMedicalCenter,Pittsburgh,PA15261,USA CorrespondenceshouldbeaddressedtoDavidK.C.Cooper,cooperdk@ Received21July2011;Revised1September2011;Accepted18September2011 AcademicEditor:KazuhikoYamada Copyright?2011Hao-ChihTaietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Allograft/xenograftrejectionisassociatedwith“passengerleukocyte”migrationfromtheorganintorecipientlymphnodes.In Study1,weattemptedtodepleteleukocytesfrompotentialkidney“donor”pigs,usingtworegimensoftotalbodyirradiation.A doseof700cGywasadministered,followedbyeither800cGy(“low-dose”)or1,300cGy(“highdose”)withthekidneysshielded. Neitherregimenwasentirelysuccessfulindepletingallleukocytes,althoughremainingTand8cellnumberswerenegligible. Study2wasaimedatprovidinganindicationofwhethernear-completedepletionofleukocyteshadanymajorimpactonkidney allograftsurvival.Innon-immunosuppressedrecipientpigs,survivalofakidneyfromadonorthatreceivedhigh-doseirradiation wascomparedwiththatofakidneytakenfromanon-irradiateddonor.Kidneygraftsurvival was9and7days,respectively, suggestingthatdepletionhadlittleimpactongraftsurvival.Thelackofe?ectmayhavebeenrelatedto(i)inadequatedepletionof passengerleukocytes,thusnotpreventingadirectTcellresponse,(ii)thepresenceofdeadordyingleukocyte