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Automated Quantitative Assessment of Proteins Biological Function in Protein Knowledge Bases英文文献资料.doc

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Automated Quantitative Assessment of Proteins Biological Function in Protein Knowledge Bases英文文献资料

HindawiPublishingCorporation AdvancesinBioinformatics Volume2008,ArticleID897019,7pages doi:10.1155/2008/897019 ResearchArticle AutomatedQuantitativeAssessmentofProteins’Biological FunctioninProteinKnowledgeBases GabrieleMayr, G¨unterLepperdinger, andPeterLackner 1 2 1 1 2 DepartmentofMolecularBiology,UniversitySalzburg,HellbrunnerStrasse34,5020Salzburg,Austria InstituteforBiomedicalAgingResearch,AustrianAcademyofSciences,Rennweg10,6020Innsbruck,Austria CorrespondenceshouldbeaddressedtoPeterLackner,peter.lackner@sbg.ac.at Received29February2008;Revised30April2008;Accepted12May2008 RecommendedbyRitaCasadio Primaryproteinsequencedataarearchivedindatabasestogetherwithinformationregardingcorrespondingbiologicalfunctions. Inthisrespect,UniProt/Swiss-Protiscurrentlythemostcomprehensivecollectionanditisroutinelycross-examinedwhentrying tounravelthebiologicalroleofhypotheticalproteins.Bioscientistsfrequentlyextractsingleentriesandfurtherevaluatethoseon asubjectivebasis.Inlieuofastandardizedprocedureforscoringtheexistingknowledgeregardingindividualproteins,wehere reportaboutacomputer-assistedmethod,whichweappliedtoscorethepresentknowledgeaboutanygivenSwiss-Protentry. Applyingthisquantitativescoreallowsthecomparisonofproteinswithrespecttotheirsequenceyethighlightsthecomprehension offunctionaldata.pfsanalysismaybealsoappliedforqualitycontrolofindividualentriesorfordatabasemanagementinorder torankentrylistings. Copyright?2008GabrieleMayretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. 1.Introduction overall goal in this context is to increase the general and detailedunderstandingaboutgenomesandproteomes. UniProtKB/Swiss-Prot and UniProtKB/TrEMBL store protein primary data and associated biological and biochemical information. These two are often used as theprimesourcefordatamining.Inthisstudy