Axial Skeletal Location Predicts Poor Outcome in Ewings Sarcoma A Single Institution Experience英文文献资料.docVIP

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Axial Skeletal Location Predicts Poor Outcome in Ewings Sarcoma A Single Institution Experience英文文献资料.doc

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Axial Skeletal Location Predicts Poor Outcome in Ewings Sarcoma A Single Institution Experience英文文献资料

Hindawi Publishing Corporation Sarcoma Volume 2011, Article ID 395180, 5 pages doi:10.1155/2011/395180 ClinicalStudy AxialSkeletalLocationPredictsPoorOutcomeinEwing’s Sarcoma:ASingleInstitutionExperience KurtR.Weiss, 6 1 DavidJ.Biau, 2 RejBhumbra, 3 AnthonyM.Grif?n, PeterC.Ferguson, 4 MartinE.Blackstein, 5 andJayS.Wunder PeterChung, CharlesCatton, 6 BrianO’Sullivan, 6 4 4 1 2 3 4 5 6 MusculoskeletalOncologyDivision,DepartmentofOrthopaedicSurgery,UniversityofPittsburgh,Pittsburgh,PA15213,USA DepartmentofOrthopaedicSurgery,UniversityofBritishColumbia,Vancouver,BC,CanadaV5Z4E3 BoneandSoftTissueTumourService,RoyalNationalOrthopaedicHospital,MiddlesexHA74LP,UK MusculoskeletalOncologyUnit,DivisionofOrthopaedicSurgery,MountSinaiHospital,Toronto,ON,CanadaM5G1X5 DepartmentofMedicine,MountSinaiHospital,Toronto,ON,CanadaM5G1X5 DepartmentofRadiationOncology,PrincessMargaretHospital,Toronto,ON,CanadaM5G2M9 Correspondence should be addressed to Kurt R. Weiss, weisskr@ Received 15 August 2011; Accepted 20 September 2011 Academic Editor: R. Pollock Copyright ? 2011 Kurt R. Weiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Ewing’s sarcomas (EWSs) of bone and soft tissue are neuroectodermal tumors that a?ect both axial and appendicular locations. We hypothesized that axial location predicted poor outcome in EWS patients. Materials and Methods. Sixty-seven patients (57 with bone EWSand 10 with soft tissue EWS) were identi?ed from our database. Thirty-four (51%) had axial EWSand 33 (49%) had appendicular EWS. Statistical analyses identi?ed predictors of poor outcome.ResultsandDiscussion. Axial location, large size, metastases at presentation, lack of de?nitive treatment, and positive surgical margins all correlated with poor outcome in univariate analysis. In multivariate analysis,