Aβ Damages Learning and Memory in Alzheimer’s Disease Rats with Kidney-Yang Deficiency英文文献资料.docVIP

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Aβ Damages Learning and Memory in Alzheimer’s Disease Rats with Kidney-Yang Deficiency英文文献资料.doc

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Aβ Damages Learning and Memory in Alzheimer’s Disease Rats with Kidney-Yang Deficiency英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID132829,9pages doi:10.1155/2012/132829 ResearchArticle AβDamagesLearningandMemoryinAlzheimer’sDiseaseRats withKidney-YangDe?ciency DongmeiQi, YongfaQiao, XinZhang, HuijuanYu, BinCheng, 1 2 1 1 1andHaifaQiao1,3,4 1 2 3 NeuroscienceProgram,ShandongUniversityofTraditionalChineseMedicine,ChangqingUniversityPark,Jinan250355,China QingdaoHaiciMedicalGroup,4RenminRoad,Qingdao266033,China InstituteofAcupunctureandMoxibustion,ChinaAcademyofChineseMedicalSciences,16Nanxiaojie,Dongzhimeinei, Beijing100700,China 4 DepartmentofBiomedicalSciences,FloridaStateUniversityCollegeofMedicine,1115WestCallStreet,Tallahassee,FL32306,USA CorrespondenceshouldbeaddressedtoHaifaQiao,haifa.qiao@ Received9January2012;Accepted18February2012 AcademicEditor:Shi-BingSu Copyright?2012DongmeiQietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. PreviousstudiesdemonstratedthatAlzheimer’sdiseasewasconsideredastheconsequenceproducedbyde?ciencyofKidney essence.However,themechanismunderlyingthesymptomsalsoremainselusive.Herewereportthatspatiallearningandmemory, escape,andswimmingcapacitiesweredamagedsigni?cantlyinKidney-yangde?ciencyrats.Indeed,bothhippocampalAβ40 and 42increasesinKidney-yangde?ciency contributetothelearningandmemory impairments.Speci?cally, damageofsynaptic plasticityisinvolvedinthelearningandmemoryimpairmentofKidney-yangde?ciencyrats.Wedeterminedthatthelearningand memorydamageinKidney-yangde?ciencyduetosynapticplasticityimpairmentandincreasesofAβ40and42wasnotcaused viaNMDAreceptorinternalizationinducedbyAβincrease.β-Adrenergicreceptoragonistcanrescuetheimpairedlong-term potential(LTP)inKidney-yangrats.Takentogether,ourresultssuggestthatspatiallearningandmemoryinhibitedinKidney- yangde?ciencymightbe