Basic Experimental Pancreatitis Models for Beginners英文文献资料.docVIP

Surgical Science, 2010, 1, 31-39 doi:10.4236/ss.2010.12007 Published Online October 2010 (http://www.SciRP.org/journal/ss) Basic Experimental Pancreatitis Models for Beginners Baris D. Yildiz , Erhan Hamaloglu 1 2 Ankara Numune Teaching Hospital 6th General Surgery, Ankara,Turkey 1 2 Hacettepe University Faculty of Medicine General Surgery Department, Sihhiye, Turkey E-mail: baris104@, barisy@.tr Received July 6, 2010; revised August 3, 2010; accepted August 10, 2010 Abstract Efforts to find an ideal model for pancreatitis date back to 1960’s. Many models are suggested since then. Every model has its own advantages and disadvantages. Some of these models test etiology while others simulate the complications of pancreatitis. An ideal model which by itself demonstrates all aspects of pan- creatitis including systemic changes is yet to be described. In this review we tried to gather the basic, easy to construct models. Keywords: Pancreatitis, Experimental Models, Closed Duodenal Loop, Arginine Induced, Ex Vivo Perfusion Model, Duct Obstruction, Taurocholate Injection, Vascular Induced 1. Introduction to PD causing pancreatitis. Closed loop is constructed with duodenum surrounding the opening of the PD. This model was first described by Seidel and popular- ized later by Pfeffer [1]. The first species used were dogs but rats were used later on. In dogs, duodenum is re- sected distal to pylorus and opening of PD then double layer sutured. The continuity of the gastrointestinal tract is maintained by gastrojejunostomy and common bile duct is obliterated with sutures [3]. Acute pancreatitis (AP) is inflammation of pancreatic tissue which can present in a wide spectrum ranging from edema of the organ to necrosis and hemorrhage. Acute pancreatitis is a multi-etiology disease with con- troversial physiopathology. Thus, it has an unpredictable course without a ta