Be Careful, Mom and Doc Hepatotoxicity Associated with Prescribed Medications in Young Infants英文文献资料.docVIP

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Be Careful, Mom and Doc Hepatotoxicity Associated with Prescribed Medications in Young Infants英文文献资料.doc

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Be Careful, Mom and Doc Hepatotoxicity Associated with Prescribed Medications in Young Infants英文文献资料

HindawiPublishingCorporation InternationalJournalofPediatrics Volume2009,ArticleID673269,3pages doi:10.1155/2009/673269 CaseReport BeCareful,MomandDoc:HepatotoxicityAssociatedwith PrescribedMedicationsinYoungInfants Kam-LunEllisHon andAlexanderK.C.Leung 1 2 1 2 DepartmentofPediatrics,TheChineseUniversityofHongKong,PrinceofWalesHospital,Shatin,HongKong DepartmentofPediatrics,AlbertaChildren’sHospital,UniversityofCalgary,Calgary,AB,CanadaT2W3N2 CorrespondenceshouldbeaddressedtoKam-LunEllisHon,ehon@.hk Received31October2008;Accepted27February2009 RecommendedbyTaiFaiFok Accidentalpoisoningsinyounginfantsarerelativelyuncommon,andthecarelesscaregiverisusuallytheculprit.Wereporttwo casesofhepatotoxicityduetoprescribedmedications.Aninfantwasgiven15mLinsteadof1.5mLofparacetamolbyhismother becausesheomittedthedecimalpointonthelabelofthedrugbottle.Theinfantbecamesymptomatic,andliverenzymeand clottingpro?lewereabnormal,necessitatingtreatmentwithN-acetylcysteine.Anotherinfantwasprescribedoralketoconazole forthrush,resultinginelevationofliverenzymes.Theserumalanineaminotransferaselevelsweretransientlyelevatedbutreturned tonormal,andbothinfantsrecovereduneventfully.Thisreportservestoalertthedoctortoavoidusingdecimalpointsindrug labelingandtoavoidprescribingexcessiveamountofdrugfortrivialacuteillness.Thrushininfancyiscommonandusually treatedwithoralnystatin.Otheroralantifungalssuchasketoconazolemaybeassociatedwithliverderangementandshouldbe avoidedininfants. Copyright?2009K.-L.E.HonandA.K.C.Leung. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. 1.Introduction insteadof1.5mLofparacetamolthreetimesadaybecause she omitted the decimal point on the label of the drug bottle. Three doses of 15mL (containing 160mg/5mL of paracetamol)weregivenat2.5and11hoursapart,respec- tively. The estimated total amount of p