Biodistribution and biocompatibility investigation in magnetoliposome treated mice英文文献资料.docVIP

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Biodistribution and biocompatibility investigation in magnetoliposome treated mice英文文献资料.doc

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Biodistribution and biocompatibility investigation in magnetoliposome treated mice英文文献资料

Spectroscopy18(2004)597–603 IOSPress 597 Biodistributionandbiocompatibility investigationinmagnetoliposometreated mice ,L.M.Lacava ,R.B.Azevedo ,O.Silva ,F.Pelegrini , Z.G.M.Lacavaa,?,V.A.P.Garciaa a a b b d M.DeCuyper c andP.C.Morais aUniversidadedeBrasília,InstitutodeCiênciasBiológicas,70910-900,Brasília-DF,Brazil bUniversidadeFederaldeGoiás,InstitutodeFísica,74001-970,Goiania-GO,Brazil cK.U.LeuvenCampusKortrijk,InterdisciplinaryResearchCenter,E.Sabbelaan53,B-8500Kortrijk, Belgium dUniversidadedeBrasília,InstitutodeFísica,NúcleodeFísicaAplicada,70919-970,Brasília-DF, Brazil Abstract.Magnetoliposomes (ML’s) maybesuccessfullyapplied forseveral purposes. A dimyristoylphosphatidyl-choline- basedML(ML-2)samplewasdevelopedasaprecursorofmorecomplexthermalcancertherapysystems.Thepresentstudy reportsonmorphologyandmagneticresonance(MR)investigationscarriedoutwiththemagnetite-basedML-2sample.For theexperiments,adultfemaleSwissmicewereendovenouslytreatedwithabolusdoseof100μlofML-2.Morphologyand room-temperatureMRstudies(X-bandexperiments)wereperformedinseveralorganscollectedfrom1hourto28daysafter MLadministration.Histologicaldatashowedmagneticnanoparticle(MNP)clustersuptothe28thdayintheliverandspleen tissues.InspiteofthepresenceofMNPclusters,nomorphologicalalterationswereobserved,supportingthebiocompatibilityof theML-2.MRsignalwasdetectedonlyintheliverandspleentissuesandshowedthattheMNP’sconcentrationwasnotaltered from48hoursto28 daysafterML injection.UsingMR data,important pharmacokinetic parameters, such astheeffective clearance(half-life)andpeakconcentration,wereobtainedfortheliverandspleen. Keywords:Biocompatibility,biodistribution,cancer,magneticresonance,magnetoliposome,morphology 1. Introduction Magneticresonance(MR)hasbeenprovedtobeanexcellenttechniquetoinvestigatenanomagnetic particlesintroducedinlivingbeings[1–3].Thecapabilityofthetechniquetosenseaslittleas100pmoles ofnanosizedmaterialsandtoprobethesizea