Bioengineering of Improved Biomaterials Coatings for Extracorporeal Circulation Requires Extended Observation of Blood-Biomaterial Interaction under Flow英文文献资料.docVIP

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Bioengineering of Improved Biomaterials Coatings for Extracorporeal Circulation Requires Extended Observation of Blood-Biomaterial Interaction under Flow英文文献资料.doc

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Bioengineering of Improved Biomaterials Coatings for Extracorporeal Circulation Requires Extended Observation of Blood-Biomaterial Interaction under Flow英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2007,ArticleID29464,10pages doi:10.1155/2007/29464 ResearchArticle BioengineeringofImprovedBiomaterialsCoatingsfor ExtracorporealCirculationRequiresExtendedObservationof Blood-BiomaterialInteractionunderFlow KrisN.J.Stevens,1YvetteB.J.Aldenhoff,2FrederikH.vanderVeen,1JosG.Maessen,1andLeoH.Koole1 1 2 DepartmentofCardiothoracicSurgery,AcademicHospitalMaastricht,P.O.Box5800,6200MDMaastricht,TheNetherlands CentreforBiomaterialsResearch,UniversityofMaastricht,P.O.Box616,6200MDMaastricht,TheNetherlands CorrespondenceshouldbeaddressedtoLeoH.Koole,l.koole@bioch.unimaas.nl Received3April2007;Revised4July2007;Accepted3December2007 RecommendedbyJohnL.McGregor Extendeduseofcardiopulmonarybypass(CPB)systemsisoftenhamperedbythrombusformationandinfection.Partofthese problemsrelatestoimperfecthemocompatibilityoftheCPBcircuitry.Theengineeringofbiomaterialsurfaceswithgenuinelong- termhemocompatibilityisessentiallyvirginterritoryinbiomaterialsscience.Forexample,mostexperimentswiththewell-known Chandlerloopmodel,forevaluationofblood-biomaterialinteractionsunder?ow,havebeendescribedforamaximumduration of2hoursonly.ThisstudyreportsasystematicevaluationoftwocommercialCPBtubings,eachwithahemocompatiblecoating, andoneuncoatedcontrol.Theexperimentscomprised(i)testingover5hoursunder?ow,withhumanwholebloodfrom4di?er- entdonors;(ii)measurementofessentialbloodparametersofhemocompatibility;(iii)analysisoftheluminalsurfacesbyscanning electronmicroscopyandthrombingenerationtimemeasurements.Thedatasetindicateddi?erencesinhemocompatibilityofthe tubings.Furthermore,itappearedthatdiscriminationbetweenbiomaterialcoatingscanbemadeonlyafterseveralhoursofblood- biomaterialcontact.Plateletcounting,myeloperoxidasequanti?cation,andscanningelectronmicroscopyprovedtobethemost usefulmethods.These?ndingsarebelievedtoberelevantwithrespecttothebioengineeringofextracorporealdevicesthatshould functionincontactwithbloodforextendedtime. Copyright