Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs英文文献资料.docVIP

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Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs英文文献资料.doc

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Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2012,ArticleID507294,9pages doi:10.1155/2012/507294 ResearchArticle BioequivalenceandPopulationPharmacokineticModelingof TwoFormsofAntibiotic,CefuroximeLysineand CefuroximeSodium,afterIntravenousInfusioninBeagleDogs LongshanZhao, QingLi, XingangLi, RanYin, XiaohuiChen, 1 1 2 1 1 LuluGeng, andKaishunBi 1 1 1 2 SchoolofPharmacy,ShenyangPharmaceuticalUniversity,Shenyang110016,China DepartmentofPharmacy,BeijingTiantanHospitalA?liatedtoCapitalMedicalUniversity,Beijing100050,China CorrespondenceshouldbeaddressedtoKaishunBi,bikaishun@ Received22January2012;Accepted14May2012 AcademicEditor:AndreVanWijnen Copyright?2012LongshanZhaoetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Toinvestigatethebioequivalenceandthepopulationpharmacokineticsofcefuroximelysineandcefuroximesodiuminhealthy beagledogs.Arandomized2-periodcrossoverdesignin18healthybeagledogsafterreceiving20,40,and80mg/kgofcefuroxime lysine or cefuroxime sodium was conducted. A 3-compartment open model was used as the basic model for the population pharmacokineticstudy.Bothoftheantibioticsexhibiteddose-proportionalpharmacokineticsoverthedoserangeof20–80mg/kg. Themeanrelativebioavailabilityofcefuroximelysineversuscefuroximesodiumwas1.05(range,0.71to1.42),withasigni?cant di?erencebetweenmalesandfemales.TheestimatesofpopulationpharmacokineticofCL,V1,Q2,V2,Q3,V3were3.74mL/h, 1.70mL,29.5mL/min,3.58mL,0.31mL/min,and158mLforcefuroximelysineand4.10mL/h,1.00mL,38.5mL/min,4.19mL, 0.06mL/min,and13.6mLforcefuroximesodium,respectively.Theinter-individualvariabilitywasdeterminedtobelessthan 29.1%.Alinearpharmacokineticwasrevealedforcefuroximelysineandcefuroximesodiumindogsafterintravenousinfusion, andthebioequivalenceoftheseformsoftheantibioticwasobservedwith