Bioengineering functional copolymers. XII. Interaction of boron-containing and PEO branched derivatives of poly(MA-alt-MVE) with HeLa cells英文文献资料.docVIP

Vol.2, No.1, 51-61 (2010) Health doi:10.4236/health.2010.21009 Bioengineering functional copolymers. XII. Interaction of boron-containing and PEO branched derivatives of poly(MA-alt-MVE) with HeLa cells Mustafa Türk , Zakir M. O. Rzayev , Gülcihan Kurucu 1 2,* 2 1 2 Department of Biology, Faculty of Science and Art, K?r?kkale University, Yahsihan, 71450 Kirikkale, Turkey Department of Chemical Engineering, Faculty Engineering, Hacettepe University, Beytepe, 06800 Ankara, Turkey; Correspondence author: zmo@.tr Received 20 October 2009; revised 20 November 2009; accepted 11 November 2009. ABSTRACT due to their nontoxic, cell-compatible, biodegradable, stimuli-responsive properties, and therefore, a wide range of biomedical and bioengineering applications exist as drug or enzyme carriers and biomacromolecular conju- gates both in diagnostics and chemotherapy as effective antitumor agents [1-8]. It is known that these copolymers can be regarded as pre-activated polymers due to the presence of anhydride moieties susceptible to the reaction with a primary amine of a biomolecule [9]. The alternat- ing copolymers of maleic anhydride (MA) with methyl vinyl ether (MVE) or divinyl ether (DVE) were utilized in various applications in diagnostics [10,11] and in che- motherapy as effective antitumor agents [8]. Poly (MA-alt-DVE), known as pyran copolymer is one of the well known bioengineering polymers having a wide range of biological activity. It processes antitumor, anti- viral, antibacterial and antifungal activities, induces in- terferon formation, and acts as an anticoagulant and anti-inflammatory agent [8,12-17]. Hirano et al. [18,19] reported that the poly (MA-alt-DVE) conjugated with bovine erythrocyte superoxide dismutase (SOD) is re- sistant against the proteolytic enzymes in