Bioengineering Functional Copolymers. XVII. Interaction of Organoboron Amide-Ester Branched Derivatives of Poly(Acrylic Acid) with Cancer Cells英文文献资料.docVIP

Journal of Cancer Therapy, 2011, 2, 266-275 doi:10.4236/jct.2011.22034 Published Online June 2011 (http://www.SciRP.org/journal/jct) Bioengineering Functional Copolymers. XVII. Interaction of Organoboron Amide-Ester Branched Derivatives of Poly(Acrylic Acid) with Cancer Cells Mustafa Türk , Gülten Kahraman , Sevda A. Khalilova , Zakir M. O. Rzayev , Serpil Oguztüzün 1 2 3 4* 1 1 Department of Biology, Faculty of Arts and Sciences, K?r?kkale University, Yah?ihan, Turkey; Training Center, Turkish Atomic Energy Authority, Ankara, Turkey; Scientific Research Institute of Medicinal Prophylaxis, Minis- Institute of Science Engineering, Division of Nanoscience and Nanomedicine, Hacettepe 2 Sarayk?y Nuclear Research and 3 try of Public Health, Baku, Azerbaijan; 4 University, Ankara, Turkey. Email: zmo@.tr Received January 11 , 2011; revised May 20 , 2011; accepted May 30 , 2011. th th th ABSTRACT Novel bioengineering functional organoboron polymers were synthesized by 1) amidolysis of poly(acrcylic acid) (PAA) with 2-aminoethyldiphenyl borinate (2-AEPB), 2) esterification of organoboron PAA polymer (PAA-B) with ?-hydroxy-?-methoxypoly(ethylene oxide) (PEO) as a compatibilizer and 3) conjugation of organoboron PEO branches (PAA-B-PEO) with folic acid (FA) as a targeting agent. Structure and composition of the synthesized poly- mers were characterized by FTIR-ATR and H ( C) NMR spectroscopy, chemical and physical analysis methods. Anti- 1 13 tumor activity of organoboron functional polymer and its complex with FA (PAA-B-PEO-F) against cancer and normal cells were evaluated by using d