Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimers Disease-Related Genes by In Silico Promoter Analysis and Microarrays英文文献资料.docVIP

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Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimers Disease-Related Genes by In Silico Promoter Analysis and Microarrays英文文献资料.doc

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Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimers Disease-Related Genes by In Silico Promoter Analysis and Microarrays英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofAlzheimer’sDisease Volume2011,ArticleID154325,13pages doi:10.4061/2011/154325 ResearchArticle BioinformaticsIdenti?cationofModulesofTranscription FactorBindingSitesinAlzheimer’sDisease-RelatedGenesby InSilicoPromoterAnalysisandMicroarrays ReginaAugustin, StefanF.Lichtenthaler, MichaelGreeff, JensHansen, 1 2 3 1 WolfgangWurst,1,2,4andDietrichTr¨umbach 1,4 1 InstituteofDevelopmentalGenetics,HelmholtzCentreMunich,GermanResearchCentreforEnvironmentalHealth(GmbH), TechnicalUniversityMunich,Ingolst¨adterLandstra?e1,Munich85764,Neuherberg,Germany DZNE,GermanCenterforNeurodegenerativeDiseases,Schillerstra?e44,80336Munich,Germany InstituteofBioinformaticsandSystemsBiology,HelmholtzCentreMunich,GermanResearchCentreforEnvironmentalHealth (GmbH),Ingolst¨adterLandstra?e1,Munich85764,Neuherberg,Germany 2 3 4 ClinicalCooperationGroupMolecularNeurogenetics,MaxPlanckInstituteofPsychiatry,Kraepelinstra?e,2-10, 80804Munich,Germany CorrespondenceshouldbeaddressedtoWolfgangWurst,wurst@helmholtz-muenchen.deand DietrichTr¨umbach,dietrich.truembach@helmholtz-muenchen.de Received21December2010;Accepted15February2011 AcademicEditor:Je?Kuret Copyright?2011ReginaAugustinetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. ThemolecularmechanismsandgeneticriskfactorsunderlyingAlzheimer’sdisease(AD)pathogenesisareonlypartlyunderstood. Toidentifynewfactors,whichmaycontributetoAD,di?erentapproachesaretakenincludingproteomics,genetics,andfunctional genomics.Here,weusedabioinformaticsapproachandfoundthatdistinctAD-relatedgenessharemodulesoftranscriptionfactor bindingsites,suggestingatranscriptionalcoregulation.Todetectadditionalcoregulatedgenes,whichmaypotentiallycontributeto AD,weestablishedanewbioinformaticswork?owwithknownmultivariatemethods