Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations英文文献资料.docVIP

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Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations英文文献资料.doc

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Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID514134,7pages doi:10.1155/2012/514134 ResearchArticle BiologicalActivitiesofLibidibia(Caesalpinia)ferreavar. parvifolia(Mart.exTul.)L.P.QueirozPodPreparations A.C.C.Freitas, T.U.L.Lins, L.R.Magalh?aes, T.Gonc?alves-Silva, andM.T.S.Correia 1 N.C.A.Ximenes, 2 1 J.S.Aguiar, 2 S.C.Nascimento, M.G.Carneiro-da-Cunha, 1 2 2 L.C.B.B.Coelho, 1 2 1 1 Laborat′oriodeGlicoprote′?nas,DepartamentodeBioqu′?mica,CentrodeCi?enciasBiol′ogicas,UniversidadeFederaldePernambuco (UFPE),AvenidaProfessorMoraesRegos/n,CidadeUniversit′aria,50670-420Recife,PE,Brazil 2 Laborat′oriodeBioensaiosparaPesquisadeF′armacos,DepartamentodeAntibi′oticos,CentrodeCi?enciasBiol′ogicas,Universidade FederaldePernambuco(UFPE),AvenidaProfessorMoraesRegos/n,CidadeUniversit′aria,50670-420Recife,PE,Brazil CorrespondenceshouldbeaddressedtoM.T.S.Correia,terezacorreia.ufpe@ Received13February2012;Revised25March2012;Accepted26March2012 AcademicEditor:AndreasSandner-Kiesling Copyright?2012A.C.C.Freitasetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. LibidibiaferreahasbeenusedinfolkmedicinethroughoutBrazil,andthisstudyevaluatedthebiologicalactivitiesofcrudeextract (CE)aswellasapartiallypuri?edfraction(F80)obtainedfromitspods.ResultsfromtheMTTassayrevealedthatonlyF80 inhibitedNCI-H292cellgrowth;however,neitherCEnorF80reducedHEp-2cellgrowthorsarcoma180tumorweightwiththein vivoassay.AcuteoraltoxicityoftheextractandfractionwasevaluatedfollowingthestepsofGuideline423,usingfemalemice;LD50 forbothpreparationswasdeterminedas2,500mg/kgbodyweight.CEandF80promotedareductionoftheleukocytenumber andnitritelevelinin?ammatoryexudateswhentheanti-in?ammatoryassay(carrageenan-inducedperitonitis)wasperformed. CEandF80inhibitedwrithingregardingantinociceptiveactivity(aceticacid-inducedwrithingrespons