Biological Activity of Betulinic Acid A Review英文文献资料.docVIP

Pharmacology Pharmacy, 2012, 3, 119-123 119 /10.4236/pp.2012.32018 Published Online April 2012 (http://www.SciRP.org/journal/pp) Biological Activity of Betulinic Acid: A Review Mansour Ghaffari Moghaddam , Faujan Bin H. Ahmad , Alireza Samzadeh-Kermani 1 2* 1 1 2 Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran; Department of Chemistry, Faculty of Science, Uni- versiti Putra Malaysia, Selangor, Malaysia. * Email: faujan@.my Received January 15 , 2012; revised February 18 , 2012; accepted March 6 , 2012 th th th ABSTRACT Betulinic acid is a known natural product which has gained a lot of attention in the recent years since it exhibits a vari- ety of biological and medicinal properties. This review provides the most important biological properties of betulinic acid. Keywords: Betulinic Acid; Betulin; Triterpene; Natural Product; Medicinal Properties 1. Introduction Betulinic acid was isolated from the MeOH extract of the aerial part of Vietnamese Orthosiphon stamineus and tested for its cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells [30]. It was found that betulinic acid shows the cytotoxicity with an ED50 value of 75.4 μg/ml. Betulinic acid was obtained from the ethanol extract of Engelhardtia serrata Bl. by bioassay-guided isolation and was tested for its cytotoxic and apoptosis-inducing activities against the K562 cell line [31]. Betulinic acid showed an inhibitory activity on the growth of K562 tu- mor cell line with IC50 value of 6.25 μg/ml and also in- duced 35% apoptosis at 25 μg/ml. Betulinic acid was isolated from the CHCl3 extract of the bark of Bischofia javanica and was eva