Balanophora spicata and Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory Activities In Vivo and In Vitro英文文献资料.docVIP

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Balanophora spicata and Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory Activities In Vivo and In Vitro英文文献资料.doc

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Balanophora spicata and Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory Activities In Vivo and In Vitro英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID371273,10pages doi:10.1155/2012/371273 ResearchArticle BalanophoraspicataandLupeolAcetatePossessAntinociceptive andAnti-In?ammatoryActivitiesInVivoandInVitro Yuh-FungChen,1,2ChienChing,2Tian-ShungWu,3,4,5Chi-ReiWu,6 andHuei-YannTsai 1,2 Wen-TsongHsieh, 1 1 2 3 4 5 6 DepartmentofPharmacology,ChinaMedicalUniversity,No.91Hsueh-ShihRoad,Taichung40402,Taiwan DepartmentofPharmacy,ChinaMedicalUniversityHospital,Taichung40427,Taiwan CollegeofPharmacy,ChinaMedicalUniversity,Taichung40402,Taiwan ChineseMedicineResearchandDevelopmentCenter,ChinaMedicalUniversityHospital,Taichung40427,Taiwan DepartmentofChemistry,NationalChengKungUniversity,Tainan70101,Taiwan SchoolofChinesePharmaceuticalSciencesandChineseMedicineResources,ChinaMedicalUniversity,Taichung40402,Taiwan CorrespondenceshouldbeaddressedtoHuei-YannTsai,pharmacology2222@ Received3May2012;Revised6October2012;Accepted9October2012 AcademicEditor:KeRen Copyright?2012Yuh-FungChenetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Aimsofthepresentstudyweretoinvestigatee?ectsofBalanophoraspicata(BS)onantinociceptionandanti-in?ammationbothin vivoandinvitro.CrudeextractofBSinhibitedvascularpermeabilityinducedbyhistamine,serotonin,bradykinin,andPGE2 ,but notbyPAF.Furthermore,BScrudeextract,di?erentlayers(n-hexane,ethylacetate,n-butanol,andwaterlayer),andlupeolacetate had signi?cant antinociceptive and anti-in?ammatory e?ects on acetic acid-induced abdominal writhing response, formalin- inducedlickingbehavior,carrageenan-,andserotonin-inducedpawedema.Then-hexanelayerhadthemoste?ectivepotency amongalllayers(IC50:67.33mg/kgonwrithingresponse;IC50s:34.2mg/kgand21.29mg/kgontheearlyphaseandlatephaseof formalintest,resp.).Additionally,lupeolacetatewhichwasisolatedfromthen-hexanelayero