Bioinformatics Methods for Learning Radiation-Induced Lung Inflammation from Heterogeneous Retrospective and Prospective Data英文文献资料.docVIP

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Bioinformatics Methods for Learning Radiation-Induced Lung Inflammation from Heterogeneous Retrospective and Prospective Data英文文献资料.doc

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Bioinformatics Methods for Learning Radiation-Induced Lung Inflammation from Heterogeneous Retrospective and Prospective Data英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2009,ArticleID892863,14pages doi:10.1155/2009/892863 ResearchArticle BioinformaticsMethodsforLearningRadiation-Induced LungIn?ammationfromHeterogeneousRetrospectiveand ProspectiveData SarahJ.Spencer, andIssamElNaqa 1 DamianAlmironBonnin, JosephO.Deasy, JeffreyD.Bradley, 2 1 1 1 1 2 DepartmentofRadiationOncology,WashingtonUniversityMedicalSchool,SaintLouis,MO63110,USA BiochemistryDepartment,EarlhamCollege,Richmond,IN47374,USA CorrespondenceshouldbeaddressedtoIssamElNaqa,elnaqa@wustl.edu Received14January2009;Accepted10March2009 RecommendedbyZhenqiuLiu Radiotherapyoutcomesaredeterminedbycomplexinteractionsbetweenphysicalandbiologicalfactors,re?ectingbothtreatment conditionsandunderlyinggenetics.Recentadvancesinradiotherapyandbiotechnologyprovidenewopportunitiesandchallenges forpredictingradiation-inducedtoxicities,particularlyradiationpneumonitis(RP),inlungcancerpatients.Inthiswork,weutilize dataminingmethodsbasedonmachinelearningtobuildapredictivemodeloflunginjurybyretrospectiveanalysisoftreatment planningarchives.Inaddition,biomarkersforthismodelareextractedfromaprospectiveclinicaltrialthatcollectsbloodserum samplesatmultipletimepoints.Weutilizea3-wayproteomicsmethodologytoscreenfordi?erentiallyexpressedproteinsthatare relatedtoRP.Ourpreliminaryresultsdemonstratethatkernelmethodscancapturenonlineardose-volumeinteractions,butfail toaddressmissingbiologicalfactors.Ourproteomicsstrategyyieldedpromisingproteincandidates,buttheirroleinRPaswellas theirinteractionswithdose-volumemetricsremaintobedetermined. Copyright?2009SarahJ.Spenceretal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1.Introduction The last two decades have witnessed many techno- logical advances in the development of three-dimensional treatme