Bacterial Magnetosome A Novel Biogenetic Magnetic Targeted Drug Carrier with Potential Multifunctions英文文献资料.docVIP

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Bacterial Magnetosome A Novel Biogenetic Magnetic Targeted Drug Carrier with Potential Multifunctions英文文献资料.doc

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Bacterial Magnetosome A Novel Biogenetic Magnetic Targeted Drug Carrier with Potential Multifunctions英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2011,ArticleID469031,13pages doi:10.1155/2011/469031 ReviewArticle BacterialMagnetosome:ANovelBiogeneticMagneticTargeted DrugCarrierwithPotentialMultifunctions JianboSun, YingLi, 1 2Xing-JieLiang,3,4andPaulC.Wang5 1 2 3 DepartmentofMicrobiologyandImmunology,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NY10032,USA StateKeyLaboratoriesforAgro-biotechnologyandCollegeofBiologicalSciences,ChinaAgriculturalUniversity,Beijing100193,China LaboratoryofNanomedicineandNanosafety,Division ofNanomedicineandNanobiology,NationalCenterforNanoscienceand Technology,Beijing100190,China 4 5 CASKeyLaboratoryforBiomedicalE?ectsofNanomaterialsandNanosafety,ChineseAcademyofSciences,Beijing100190,China LaboratoryofMolecularImaging,DepartmentofRadiology,HowardUniversity,Washington,DC20060,USA CorrespondenceshouldbeaddressedtoXing-JieLiang,liangxj@andPaulC.Wang,pwang@ Received30May2011;Accepted12July2011 AcademicEditor:DongluShi Copyright?2011JianboSunetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Bacterial magnetosomes (BMs) synthesized by magnetotactic bacteria have recently drawn great interest due to their unique features.BMsareusedexperimentallyascarriersforantibodies,enzymes,ligands,nucleicacids,andchemotherapeuticdrugs. Inadditiontothecommonattractivepropertiesofmagneticcarriers, BMsalsoshowsuperiority astargetingnanoscaledrug carriers,whichishardlymatchedbyarti?cialmagneticparticles.WearepresentingthepotentialapplicationsofBMsasdrug carriersbyintroducingthedrug-loadingmethodsandstrategiesandtherecentresearchprogressofBMswhichhascontributedto theapplicationofBMsasdrugcarriers. 1.Introduction usingspeci?cmoleculessuchasligandsorantibodies,which canrecognizethetargetedareaandincreasethea?nitytoit. Magnetic-targeted drug carriers are prepared using Fe3O4 or