Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells英文文献资料.docVIP

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Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells英文文献资料.doc

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Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells英文文献资料

HindawiPublishingCorporation StemCellsInternational Volume2012,ArticleID816049,10pages doi:10.1155/2012/816049 ReviewArticle BioelectricStateandCellCycleControlof MammalianNeuralStemCells JulietaApreaandFedericoCalegari DFG-ResearchCenterandClusterofExcellenceforRegenerativeTherapies,MedicalFaculty,DresdenUniversityofTechnology, Fetscherstrasse105,01307Dresden,Germany CorrespondenceshouldbeaddressedtoFedericoCalegari,federico.calegari@crt-dresden.de Received2May2012;Accepted22July2012 AcademicEditor:StefanLiebau Copyright?2012J.ApreaandF.Calegari.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Theconcertedactionofionchannelsandpumpsestablishingarestingmembranepotentialhasbeenmostthoroughlystudied inthecontextofexcitablecells,mostnotablyneurons,butemergingevidencesindicatethattheyarealsoinvolvedincontrolling proliferationanddi?erentiationofnonexcitablesomaticstemcells.Theimportanceofunderstandingstemcellcontributionto tissueformationduringembryonicdevelopment,adulthomeostasis,andregenerationindiseasehaspromptedmanygroupsto studyandmanipulatethemembranepotentialofstemcellsinavarietyofsystems.Inthispaperweaimedatsummarizingthe currentknowledgeontheroleofionchannelsandpumpsinthecontextofmammaliancorticogenesiswithparticularemphasis ontheircontributiontotheswitchofneuralstemcellsfromproliferationtodi?erentiationandgenerationofmorecommitted progenitorsandneurons,whoselineageduringbraindevelopmenthasbeenrecentlyelucidated. 1.Introduction However,thelimitsofourknowledgeinthisareaarepar- ticularlyevident duringmammalianbraindevelopmentin whichtheestablishmentofnew,sophisticatedtoolshasonly recently allowed the characterization of the physiological lineageofNSC.Speci?cally,duringembryonicdevelopment of the mammalian cortex, polarized radial-glial cells, also referredtoasapicalprogenitors(AP)formingtheventricular zone(VZ),progressivelyswit