Biomaterial Based on Doped Calcium Carbonate-Phosphate for Active Osteogenesis英文文献资料.docVIP

Journal of Biomaterials and Nanobiotechnology, 2012, 3, 226-237 /10.4236/jbnb.2012.32028 Published Online April 2012 (http://www.SciRP.org/journal/jbnb) Biomaterial Based on Doped Calcium Carbonate-Phosphate for Active Osteogenesis Lyubov F. Koroleva , L. P. Larionov , N. P. Gorbunova 1 2* 3 1 Institute of Engineering Science of the Russian Academy of Sciences, Ural Branch, Ekaterinburg, Russia; 2 Ural State Medical Academy, Ekaterinburg, Russia; inburg, Russia. * Email: lq@imach.uran.ru 3 Institute of Geology and Geochemistry of the Russian Academy of Sciences, Ural Branch, Ekater- Received January 12 , 2012; revised February 26 , 2012; accepted March 14 , 2012 th th th ABSTRACT Doped calcium carbonate-phosphate is a biocompatible material that influence actively on the osteogenesis, bone re- generate, strengthening of bone and dental tissues including through the skin. A mechanism of the synthesis reactions of doped nanocrystalline calcium carbonate-phosphate an oscillating type of model for these reactions is proposed. The results indicate that the synthesis involves the formation of hydroxy carbonate complexes from the three calcium car- bonate polymorphs (calcite, vaterite, and aragonite) in a solution of ammonium chloride and ammonium carbonate, fol- lowed by reaction with orthophosphoric acid. The formation of nanocrystalline calcium carbonate-phosphate doped with Fe , Mg , Zn , K , Si , and Mn , has been studied by X-ray diffraction, IR spectroscopy, differential thermal 2+ 2+ 2+ + 4+ 2+ analysis, and energy dispersive X-ray fluorescence analysis. This ensures the preparation of a bioactive material based on octacalcium hydrog