Biomechanical prediction of abdominal aortic aneurysm rupture risk Sensitivity analysis英文文献资料.docVIP

J. Biomedical Science and Engineering, 2012, 5, 664-671 JBiSE /10.4236/jbise.2012.511083 Published Online November 2012 (http://www.SciRP.org/journal/jbise/) Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis Shijia Zhao , Wenlong Li , Linxia Gu 1 1 1,2* 1 2 Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, USA Nebraska Center for Materials and Nanoscience, Lincoln, USA Email: lgu2@ * Received 30 July 2012; revised 13 September 2012; accepted 20 September 2012 ABSTRACT reported a rupture rate of 12.8% for AAAs with a maxi- mum diameter less than 5 cm and 40% for AAAs with a diameter larger than 5 cm in an autopsy study [3]. Hall et al. observed that the rupture rate for AAAs with a maxi- mum diameter less than 5 cm could be up to 23% [4]. The high mortality associated with the AAA rupture and the inaccuracy of the traditional 5-cm criterion need improved surgical decision criterion to predict the AAA rupture risk [2,5]. From the biomechanical standpoint, the rupture of AAA was initiated when the local me- chanical stress on the aneurysm exceeds the failure strength of the local material [6]. Therefore, the me- chanical stress of AAAs might serve as a criterion to predict or decide the AAA rupture [7]. Vorp et al. have investigated the relationship between the mechanical stress in AAAs and the factors of maximum diameter and asymmetric bulge through three-dimensional computa- tional models in 1998 [8]. Since then, many experimental and computational studies have been conducted to inves- tigate the effects of other characteristics of aneurysm on its mechanical stress, such as the thickness of aneurysm wall [5,9-11], the properties of material [12], and hyper- tension [13]. Although different mechanical variables leading to AAA ruptur