BDKRB2 +9？9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population英文文献资料.docVIP

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BDKRB2 +9？9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population英文文献资料.doc

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BDKRB29？9PolymorphismIsAssociatedwithHigherRiskforDiabetesMellitusintheBrazilianGeneralPopulation英文文献资料

HindawiPublishingCorporation ExperimentalDiabetesResearch Volume2012,ArticleID480251,4pages doi:10.1155/2012/480251 ResearchArticle BDKRB2+9/?9PolymorphismIsAssociatedwithHigherRisk forDiabetesMellitusintheBrazilianGeneralPopulation RafaeldeOliveiraAlvim, 2 1 PauloC.J.L.Santos, 3 1 RaimundoM.Nascimento, andAlexandreC.Pereira 1 2 GeorgeL.L.M.Coelho, Jos′eG.Mill, Jos′eE.Krieger, 1 1 LaboratoryofGeneticsandMolecularCardiology,HeartInstitute(InCor),UniversityofSaoPauloMedicalSchool, AvenidaDr.En′easdeCarvalhoAguiar,44CerqueiraC′esar,05403-000S?aoPaulo,SP,Brazil DepartmentofMedicine,OuroPretoFederalUniversity,OuroPreto,MG,Brazil 2 3 DepartmentofPhysiology,EspiritoSantoFederalUniversity,Vit′oria,ES,Brazil CorrespondenceshouldbeaddressedtoAlexandreC.Pereira,acplbmpereira@ Received3October2012;Accepted1November2012 AcademicEditor:AristidisVeves Copyright?2012RafaeldeOliveiraAlvimetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Somemechanismshavebeenproposedtoexplaintheroleofbradykininonglucosehomeostasisandsomestudiesreportedthat theBDKRB2+9/?9polymorphismwasassociatedtothetranscriptionalactivityofthereceptor.Inthisscenario,themainaimof thisstudywastoevaluatetheassociationoftheBDKRB2+9/?9polymorphismwithdiabetesmellitusriskintheBraziliangeneral population.Thisstudyincluded1,032subjectsofthegeneralurbanpopulation.Anthropometrical,bloodpressure,biochemical, andgenotypeanalysesfortheBDKRB2+9/?9bpinsertion/deletionpolymorphismwereperformed.Individualscarrying+9/+9 or+9/?9genotypeshadhigherglucosevalues(84.5mg/dLversus80.6mg/dL,resp.)andhigherfrequencyofdiabetesmellitus (7.6%versus3.6%,resp.)comparedtoindividualscarrying ?9/?9,adjustingforageandgender.Inaddition,higherdiabetes mellitusriskwasassociatedtopresenceofthe+9/+9or+9/?9genotypes(OR=1.91;95%CI=1.09–4.19;P = 0.03).Ourdata suggestthattheBDKRB2+9/-9poly