Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model英文文献资料.docVIP

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Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model英文文献资料.doc

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Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model英文文献资料

HindawiPublishingCorporation OxidativeMedicineandCellularLongevity Volume2012,ArticleID194829,6pages doi:10.1155/2012/194829 ResearchArticle BisphenolAInducesHepatotoxicitythrough OxidativeStressinRatModel ZeinabK.Hassan,1,2MaiA.Elobeid, 1 PromyVirk, SawsanA.Omer, 1 1 andEbtisamM.AlOlayan 1 MahaElAmin, 1 MahaH.Daghestani, 1 1 2 ZoologyDepartment,CollegeofScience,KingSaudUniversity,Riyadh11451,SaudiArabia CancerBiologyDepartment,NationalCancerInstitute,CairoUniversity,Cairo11796,Egypt CorrespondenceshouldbeaddressedtoZeinabK.Hassan,hildahafez@ Received24March2012;Revised27April2012;Accepted6June2012 AcademicEditor:FranciscoJavierRomero Copyright?2012ZeinabK.Hassanetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Reactiveoxygenspecies(ROS)arecytotoxicagentsthatleadtosigni?cantoxidativedamage.BisphenolA(BPA)isacontaminant with increasing exposure to it and exerts both toxic and estrogenic e?ects on mammalian cells. Due to limited information concerningthee?ectofBPAonliver,thisstudyinvestigateswhetherBPAcauseshepatotoxicitybyinductionofoxidativestressin liver.Ratsweredividedinto?vegroups:The?rstfourgroups,BPA(0.1,1,10,50mg/kg/day)wereadministratedorallytoratsfor fourweeks.The?fthgroupwastakenwaterwithvehicle.The?nalbodyweightsinthe0.1mggroupshowedasigni?cantdecrease comparedtocontrolgroup.Signi?cantdecreasedlevelsofreducedglutathione,superoxidedismutase,glutathioneperoxidase, glutathione-S-transferase,glutathionereductaseandcatalaseactivitywerefoundinthe50mgBPAgroupcomparedtocontrol groups.HighdoseofBPA(50mg/kg)signi?cantlyincreasedthebiochemicallevelsofALT,ALPandtotalbilirubin.BPAe?ecton theactivityofantioxidantgeneswascon?rmedbyrealtimePCRinwhichtheexpressionlevelsofthesegenesinlivertissuewere signi?cantlydecreasecomparedtocontrol.DatafromthisstudydemonstratethatBPAgenerateROSandreducetheantioxi