Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats英文文献资料.docVIP

下载本文档

0
0
约 13页
2017-05-10 发布于上海
举报
版权申诉

Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats英文文献资料.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats英文文献资料

HindawiPublishingCorporation InternationalJournalofHypertension Volume2012,ArticleID795452,12pages doi:10.1155/2012/795452 ResearchArticle Bene?cialEffectsofLong-TermAdministrationofanOral FormulationofAngiotensin-(1–7)inInfarctedRats Fu′lviaD.Marques,1,2MarcosB.Melo, MariaClau′diaC.Irigoyen, Ru′benD.Sinisterra,1,3FredericoB.deSousa, S′?lviaQ.Savergnini,1,2Vin′?ciusB.A.Braga, AndersonJ.Ferreira,1,4andRobsonA.S.Santos 1,2 LeandroE.Souza, 1 1 1 1 4 1 NationalInstituteofScienceandTechnologyinNanobiopharmaceutics,FederalUniversityofMinasGerais, 31.270-901BeloHorizonte,MG,Brazil 2 3 4 DepartmentofPhysiologyandBiophysics,FederalUniversityofMinasGerais,31.270-901BeloHorizonte,MG,Brazil DepartmentofChemistry,FederalUniversityofMinasGerais,31.270-901BeloHorizonte,MG,Brazil DepartmentofMorphology,FederalUniversityofMinasGerais,31.270-901BeloHorizonte,MG,Brazil CorrespondenceshouldbeaddressedtoRobsonA.S.Santos,robsonsant@ Received19August2011;Accepted26October2011 AcademicEditor:MohanK.Raizada Copyright?2012Fu′lviaD.Marquesetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. In this study was evaluated the chronic cardiac e?ects of a formulation developed by including angiotensin(Ang)-(1–7) in hydroxypropyl β-cyclodextrin (HPβCD), in infarcted rats. Myocardial infarction (MI) was induced by left coronary artery occlusion.HPβCD/Ang-(1–7)wasadministeredfor60days(76μg/Kg/onceaday/gavage)startingimmediatelybeforeinfarction. Echocardiographywasutilizedtoevaluateusualcardiacparameters,andradialstrainmethodwasusedtoanalyzethevelocityand displacementofmyocardial?bersatinitialtimeand15,30,and50daysaftersurgery.Real-timePCRwasutilizedtoevaluatethe ?broticsignalinginvolvedintheremodelingprocess.Once-a-dayoralHPβCD/Ang-(1–7)administrationimprovedthecardiac functionandreducedthedeleteriouse?ectsinducedbyMIonTGF-βandcollagentypeIexpres