Beneficial Regulation of Matrix Metalloproteinases for Skin Health英文文献资料.docVIP

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Beneficial Regulation of Matrix Metalloproteinases for Skin Health英文文献资料.doc

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Beneficial Regulation of Matrix Metalloproteinases for Skin Health英文文献资料

SAGE-HindawiAccesstoResearch EnzymeResearch Volume2011,ArticleID427285,4pages doi:10.4061/2011/427285 ReviewArticle Bene?cialRegulationofMatrixMetalloproteinasesfor SkinHealth NeenaPhilips, SusanAuler, RaulHugo, 1 1 1andSalvadorGonzalez 2,3 1 2 3 SchoolofNaturalSciences,FairleighDickinsonUniversity,H-DH4-03,1000RiverRoad,Teaneck,NJ07666,USA IndustrialCantabriaFarmaceutica,S.A,Madrid,Spain DermatologyService,MemorialSloan-KetteringCancerCenter,NY10065,USA CorrespondenceshouldbeaddressedtoNeenaPhilips,neenaphilips@ Received21September2010;Accepted21December2010 AcademicEditor:Yong-DooPark Copyright?2011NeenaPhilipsetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Matrixmetalloproteinases(MMPs)areessentialtotheremodelingoftheextracellularmatrix.Whiletheirupregulationfacilitates agingandcancer,theyareessentialtoepidermaldi?erentiationandthepreventionofwoundscars.Thepharmaceuticalindustry isactiveinidentifyingproductsthatinhibitMMPstopreventortreatagingandcancerandproductsthatstimulateMMPsto preventepidermalhyperproliferativediseasesandwoundscars. 1.Introduction degrade basementmembranecollagensanddegrade dena- tured structural collagens. The stromelysins (MMP-3, -10, -11, and -19) degrade basement membrane collagens as well as proteoglycans and matrix glycoproteins. The other MMP classes include membrane-type MMPs (MT-MMP: MMP-14,-15, -16, -17,-24, and-25)thatactivateMMPs, matrilysinsthatdegradethebasementmembrane(MMP-7 and-26),elastasethatdegradesprimarilyelastin(MMP-12), and others (MMP-20, -21, -22, -23, -27, and -28). MMPs are regulated in expression or activity at several di?erent levels: gene expression, activation, and cellular inhibition ofactivitybytissueinhibitorsofmatrixmetalloproteinases (TIMPs), especially TIMP-1 and TIMP-2 [12]. Epithelial cells,?broblasts,neutrophils,andmastcellsaresomeoft