Blind Source Separation of Hemodynamics from Magnetic Resonance Perfusion Brain Images Using Independent Factor Analysis英文文献资料.docVIP

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Blind Source Separation of Hemodynamics from Magnetic Resonance Perfusion Brain Images Using Independent Factor Analysis英文文献资料.doc

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Blind Source Separation of Hemodynamics from Magnetic Resonance Perfusion Brain Images Using Independent Factor Analysis英文文献资料

HindawiPublishingCorporation InternationalJournalofBiomedicalImaging Volume2010,ArticleID360568,9pages doi:10.1155/2010/360568 ResearchArticle BlindSourceSeparationofHemodynamicsfrom MagneticResonancePerfusionBrainImagesUsing IndependentFactorAnalysis Yen-ChunChou,1,2Chia-FengLu,1,2Wan-YuoGuo,3,4andYu-TeWu1,2,5 1 DepartmentofBiomedicalImagingandRadiologicalSciences,NationalYang-MingUniversity,No.155,Section2, Li-NongStreet,Pei-Tou,Taipei112,Taiwan 2 IntegratedBrainResearchLaboratory,DepartmentofMedicalResearchandEducation,TaipeiVeteransGeneralHospital, No.201,Section2,Shih-PaiRd.,Pei-Tou,Taipei112,Taiwan 3 4 5 DepartmentofRadiology,TaipeiVeteransGeneralHospital,No.201,Section2,Shih-PaiRd.,Pei-Tou,Taipei112,Taiwan FacultyofMedicine,NationalYang-MingUniversity,No.155,Section2,Li-NongStreet,Pei-Tou,Taipei112,Taiwan InstituteofBrainSciences,NationalYang-MingUniversity,No.155,Section2,Li-NongStreet,Pei-Tou,Taipei112,Taiwan CorrespondenceshouldbeaddressedtoYu-TeWu,ytwu@.tw Received4September2009;Accepted30January2010 AcademicEditor:ShanZhao Copyright?2010Yen-ChunChouetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Perfusionmagneticresonancebrainimaginginducestemporalsignalchangesonbraintissues,manifestingdistinctblood-supply patternsfortheprofoundanalysisofcerebralhemodynamics.Weemployedindependentfactoranalysistoblindlyseparatesuch dynamicimagesintodi?erentmaps,thatis,artery,graymatter,whitematter,veinandsinus,andchoroidplexus,inconjunction withcorrespondingsignal-timecurves.Theaveragedsignal-timecurveonthesegmentedarterialareawasfurtherusedtocalculate therelativecerebralbloodvolume(rCBV),relativecerebralblood?ow(rCBF),andmeantransittime(MTT).Theaveragedratios forrCBV,rCBF,andMTTbetweengrayandwhitemattersfornormalsubjectswerecongruentwiththoseintheliterature. 1.Introduction theory [11, 12]. This has been used in t