Blood and CSF Biomarker Dynamics in Multiple Sclerosis Implications for Data Interpretation英文文献资料.docVIP

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Blood and CSF Biomarker Dynamics in Multiple Sclerosis Implications for Data Interpretation英文文献资料.doc

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Blood and CSF Biomarker Dynamics in Multiple Sclerosis Implications for Data Interpretation英文文献资料

HindawiPublishingCorporation MultipleSclerosisInternational Volume2011,ArticleID823176,6pages doi:10.1155/2011/823176 ResearchArticle BloodandCSFBiomarkerDynamicsinMultipleSclerosis: ImplicationsforDataInterpretation M.J.Eikelenboom, B.M.J.Uitdehaag, 1 1andA.Petzold 1,2 1 DepartmentofNeurology,MSCenterAmsterdam,VUUniversityMedicalCenter,Amsterdam,DeBoelelaan1117, 1081HVAmsterdam,TheNetherlands DepartmentofNeuroin?ammation,UCLInstituteofNeurology,QueenSquare,LondonWC1N3BG,UK 2 CorrespondenceshouldbeaddressedtoA.Petzold,a.petzold@ion.ucl.ac.uk Received30November2010;Accepted16February2011 AcademicEditor:HelmutButzkueven Copyright?2011M.J.Eikelenboometal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Background. Disability in multiple sclerosis (MS) is related to neuroaxonal degeneration. A reliable blood biomarker for neuroaxonal degeneration is needed. Objectives. To explore the relationship between cerebrospinal ?uid (CSF) and serum concentrations of a protein biomarker for neuroaxonal degeneration, the neuro?laments heavy chain (NfH). Methods . An exploratorycross-sectional(n=51)andlongitudinal(n=34)studyoncerebrospinal?uid(CSF)andserumNfHphosphoform levelsinpatientswithMS.Theexpandeddisabilitystatusscale(EDSS),CSF,andserumlevelsofNfH-SMI34andNfH-SMI35were quanti?edatbaseline.Disabilityprogressionwasassessedat3-yearfollowup.Results.Atbaseline,patientswithprimaryprogressive MS(PPMS,EDSS6)andsecondaryprogressiveMS(SPMS,EDSS6)weremoredisabledcomparedtopatientswithrelapsing remittingMS(RRMS,EDSS2,P .0001).SerumandCSFNfHphosphoformlevelswerenotcorrelated.Baselineserumlevels oftheNfH-SMI34weresigni?cantly(P.05)higherinpatientswithPPMS(2.05ng/mL)comparedtoSPMS(0.03ng/mL)and RRMS(1.56ng/mL).InSPMShigherserumthanCSFNfH-SMI34levelspredicteddisabilityprogressionfrombaseline(ΔEDSS 2,P.05).InRRMShigherCSFthanserumNf