Blood lipids may have influence on the emotional well-being in young men英文文献资料.docVIP

Vol.2, No.5, 441-447 (2010) Health doi:10.4236/health.2010.25066 Blood lipids may have influence on the emotional well-being in young men Edyta Kramek, Sylwia Jastrzebska, Renata Walczak-Jedrzejowska, Katarzyna Marchlewska, Elzbieta Oszukowska, Anna Guminska, Krzysztof Kula, Jolanta Slowikowska-Hilczer* Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland; *Corresponding Author: jolanta.slowikowska-hilczer@umed.lodz.pl Received 14 January 2010; revised 4 February 2010; accepted 6 February 2010. ABSTRACT nal changes in menstrual cycle and changes in mood in women [1,2]. Recent long-term, prospective studies have demonstrated that the transition to menopause is associ- ated with higher risk for new onset and recurrent depres- sion [3]. In men, however, interrelationship between the emotional state and sex steroids serum levels are con- troversial. Low testosterone serum level in hypogonadal men is characterised by depressed mood and emotional instability [4,5]. Androgen deficiency in the aging male, also referred to as late-onset hypogonadism (LOH), is a clinical and biochemical syndrome associated with ad- vancing age and deficiency in serum testosterone levels below the young healthy adult male reference range [6]. It includes, among other symptoms, depressed mood, decreased vitality and low sex drive [7,8]. Several stud- ies showed the significant improvement in the emotional well-being after testosterone [9-11] or dehydroepian- drosterone sulphate (DHEA-S) administration in hypo- gonadal men [12,13]. Nevertheless, physiologic studies were usually not successful in demonstrating a signifi- cantly negative relation of androgens with lower mood, especially in young men [14,15]. Other evidences indicate that vascular disease may cause depression and thus cerebral atherosclerosis may be responsible for late-life depressed mood [16,17]. On the othe