Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis英文文献资料.docVIP

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Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis英文文献资料.doc

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Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis英文文献资料

Research Commmunication Mediators of Inflammation, 11, 211–217 (2002) A IM : To investigate whether blood serotonin Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis (5-hydroxytryptamine) (5-HT) modulates musculos- keletal pain differently in seropositive and seronega- tive rheumatoid arthritis (RA). Methods: Patients with temporomandibular joint (TMJ) involvement of seropositive RA (33 patients) or seronegative RA (28 patients) and 26 healthy individ- ualswereincluded.TMJ pain,generalmusculoskele- tal pain, plasma and serum 5-HT, acute phase reac- tants and thrombocyte count were investigated. Results: The patients with seropositive RA had higher serum (median = 1130nmol/l) and plasma (55nmol/ l) levels of 5-HT than the healthy individuals (704nmol/l, p = 0.044 and 23nmol/l, p 0.001, respectively), and higher plasma levels of 5-HT than the seronegative patients (14nmol/l, p 0.001). There was no significant correlation between serum and plasma levels of 5-HT in any group. In the seropositive RA patients, positive correla- tions were found between serum levels of 5-HT and the number of painfulmandibularmovements (rs = 0.36, n= 33, p= 0.042), as well as pain on maximum mouth opening (rs = 0.41, n = 24, p = 0.047) and tenderness to digital palpation (rs = 0.49, n = 33, p= 0.003). Sigvard Kopp CA and Per Alstergren Department of Clinical Oral Physiology, Institute of Odontology, Karolinska Institutet, Box 4064, 141 04 Huddinge, Sweden CA Corresponding author Tel: +468 728 8281 Fax: +468 608 08 81 E-mail: sigvard.kopp@ofa.ki.se In the healthy individuals, there was a negative correlation between plasma level of 5-HT and the TMJ pressure pain threshold (rs = –0.47, n = 20, p = 0.037). Conclusion: Peripheral serotonergic pain mecha- nisms seem to be activated by blood 5-HT in patients with seropositive RA, in contrast to seronegative patients. Key words: Arthritis, Healthy, Inflammation, Nociception, Normal, Pain Th