Blood Vessel Density in Basal Cell Carcinomas and Benign Trichogenic Tumors as a Marker for Differential Diagnosis in Dermatopathology英文文献资料.docVIP
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Blood Vessel Density in Basal Cell Carcinomas and Benign Trichogenic Tumors as a Marker for Differential Diagnosis in Dermatopathology英文文献资料
HindawiPublishingCorporation
JournalofSkinCancer
Volume2011,ArticleID241382,5pages
doi:10.1155/2011/241382
ResearchArticle
BloodVesselDensityinBasalCellCarcinomasandBenign
TrichogenicTumorsasaMarkerfor
DifferentialDiagnosisinDermatopathology
JuliaWinter,HermannKneitz,andEva-B.Br¨ocker
DepartmentofDermatology,UniversityHospitalW¨urzburg,Josef-Schneider-Strar?e2,97080W¨urzburg,Germany
CorrespondenceshouldbeaddressedtoEva-B.Br¨ocker,broecker e@klinik.uni-wuerzburg.de
Received23June2010;Revised27August2010;Accepted15September2010
AcademicEditor:SilviaMoretti
Copyright?2011JuliaWinteretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,
whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
In order to get insight into the density of blood vessels in the stroma of benign and malignant trichogenic neoplasms,
immunohistologicalquanti?cationofCD31positivevesselswasperformedin112tumors,comprisedof50BCCsofnodular
(35)ormorphoeic(15)growthpatterns,17Pinkus’tumors,aswellas17trichoepitheliomasofwhich6weredesmoplastic,8
trichofolliculomas,and20trichoblastomas.Methods.Vesseldensitywascountedwithinthetumors,inthetumor-surrounding
stroma,and,asacontrol,inthenormalskinoftheoperationspecimen.Theresultswerecomparedusingstatisticalmethods.
Results.Whereas,irrespectiveofthepatients’ageandlocationoftumors,thevesseldensityinnormalskinshowednosigni?cant
di?erences (8.8 ± 2.7), the counts in the peritumoral stroma revealed signi?cant di?erences between the di?erent tumors
investigated.ThehighestcountswereobtainedinBCC(24.7± 6.7)andthelowestinbenigntrichogenicneoplasms(around
14)Pinkus’tumorsrevealedintermediatecounts(19.7± 6.6).Thevesseldensitieswithinthetumorsweregenerallylow,andno
correlationtothedignitywasfound.Conclusion.Determinationofbloodvesseldensityintheperitumoralstromamaybean
additionalparameterfordi?erentialdiagnosisoftrichogenictumorsofuncertaindignity.
1.Introduction
ofmicrovesseldens
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