Blood Vessel Density in Basal Cell Carcinomas and Benign Trichogenic Tumors as a Marker for Differential Diagnosis in Dermatopathology英文文献资料.docVIP

Blood Vessel Density in Basal Cell Carcinomas and Benign Trichogenic Tumors as a Marker for Differential Diagnosis in Dermatopathology英文文献资料.doc

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Blood Vessel Density in Basal Cell Carcinomas and Benign Trichogenic Tumors as a Marker for Differential Diagnosis in Dermatopathology英文文献资料

HindawiPublishingCorporation JournalofSkinCancer Volume2011,ArticleID241382,5pages doi:10.1155/2011/241382 ResearchArticle BloodVesselDensityinBasalCellCarcinomasandBenign TrichogenicTumorsasaMarkerfor DifferentialDiagnosisinDermatopathology JuliaWinter,HermannKneitz,andEva-B.Br¨ocker DepartmentofDermatology,UniversityHospitalW¨urzburg,Josef-Schneider-Strar?e2,97080W¨urzburg,Germany CorrespondenceshouldbeaddressedtoEva-B.Br¨ocker,broecker e@klinik.uni-wuerzburg.de Received23June2010;Revised27August2010;Accepted15September2010 AcademicEditor:SilviaMoretti Copyright?2011JuliaWinteretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. In order to get insight into the density of blood vessels in the stroma of benign and malignant trichogenic neoplasms, immunohistologicalquanti?cationofCD31positivevesselswasperformedin112tumors,comprisedof50BCCsofnodular (35)ormorphoeic(15)growthpatterns,17Pinkus’tumors,aswellas17trichoepitheliomasofwhich6weredesmoplastic,8 trichofolliculomas,and20trichoblastomas.Methods.Vesseldensitywascountedwithinthetumors,inthetumor-surrounding stroma,and,asacontrol,inthenormalskinoftheoperationspecimen.Theresultswerecomparedusingstatisticalmethods. Results.Whereas,irrespectiveofthepatients’ageandlocationoftumors,thevesseldensityinnormalskinshowednosigni?cant di?erences (8.8 ± 2.7), the counts in the peritumoral stroma revealed signi?cant di?erences between the di?erent tumors investigated.ThehighestcountswereobtainedinBCC(24.7± 6.7)andthelowestinbenigntrichogenicneoplasms(around 14)Pinkus’tumorsrevealedintermediatecounts(19.7± 6.6).Thevesseldensitieswithinthetumorsweregenerallylow,andno correlationtothedignitywasfound.Conclusion.Determinationofbloodvesseldensityintheperitumoralstromamaybean additionalparameterfordi?erentialdiagnosisoftrichogenictumorsofuncertaindignity. 1.Introduction ofmicrovesseldens

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