Blood Harmane Concentrations in 497 Individuals Relative to Coffee, Cigarettes, and Food Consumption on the Morning of Testing英文文献资料.docVIP

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Blood Harmane Concentrations in 497 Individuals Relative to Coffee, Cigarettes, and Food Consumption on the Morning of Testing英文文献资料.doc

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Blood Harmane Concentrations in 497 Individuals Relative to Coffee, Cigarettes, and Food Consumption on the Morning of Testing英文文献资料

HindawiPublishingCorporation JournalofToxicology Volume2011,ArticleID628151,6pages doi:10.1155/2011/628151 ResearchArticle BloodHarmaneConcentrationsin497Individuals RelativetoCoffee,Cigarettes,andFoodConsumptionon theMorningofTesting MarinaGerbin, WendyJiang, andWeiZheng ElanD.Louis,1,2,3,4PamFactor-Litvak,3 1 5 5 1 GHSergievskyCenter,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,Unit198,NeurologicalInstitute, 710West168thStreet,NewYork,NY10032-2699,USA 2 3 4 DepartmentofNeurology,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NY10027-6900,USA DepartmentofEpidemiology,MailmanSchoolofPublicHealth,ColumbiaUniversity,NewYork,NY10032-3727,USA TaubInstituteforResearchonAlzheimer’sDiseaseandtheAgingBrain,CollegeofPhysiciansandSurgeons, ColumbiaUniversity,NewYork,NY10032,USA 5 SchoolofHealthSciences,PurdueUniversity,WestLafayette,IN47907-2051,USA CorrespondenceshouldbeaddressedtoElanD.Louis,edl2@ Received23November2010;Revised11February2011;Accepted16February2011 AcademicEditor:MargaretJames Copyright?2011ElanD.Louisetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Harmane,apotentneurotoxinlinkedwithseveralneurologicaldisorders,ispresentinmanyfoods,co?ee,andcigarettes.We assessedwhethermorningfood/co?eeconsumptionandsmokingwerere?ectedinbloodharmaneconcentrations(BHCs)we obtainedinanepidemiologicsample(n =497).ParticipantswhosmokedonthemorningofphlebotomyhadsimilarlogBHCs tothosewhohadnotsmoked(P =.57);therewasnocorrelationbetweenlogBHCsandnumberofcigarettes(P =.59).Among theco?eedrinkers,therewasnocorrelationbetweennumberofcupsandlogBHCs(P =.98).Participantswhohadeatenonthe morningofphlebotomyhadsimilarlogBHCstothosewhohadnot(P =.49);logBHCsdidnotcorrelatewiththetimelatency betweenlastfoodconsumptionandphlebotomy(P =.74).BHCsinthissampleof～500indi