Bone Marrow Microenvironment in Multiple Myeloma Progression英文文献资料.docVIP

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2012,ArticleID157496,5pages doi:10.1155/2012/157496 ReviewArticle BoneMarrowMicroenvironmentin MultipleMyelomaProgression X.Leleu, I.M.Ghobrial, andA.M.Roccaro S.Manier,1,2A.Sacco,1 2 1 1 1 Dana-FarberCancerInstitute,DepartmentofMedicalOncology,HarvardMedicalSchool,450BrooklineAvnue, HIM246,Boston,MA02215,USA ServicedesMaladiesduSang,CHRUdeLille,59000Lille,France 2 CorrespondenceshouldbeaddressedtoA.M.Roccaro,aldo roccaro@dfci.harvard.edu Received3August2012;Accepted18September2012 AcademicEditor:Sue-HwaLin Copyright?2012S.Manieretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bonemarrow(BM)microenvironment.Indeed,theBMnicheappearstoplayanimportantroleindi?erentiation,migration, proliferation,survival,anddrugresistanceofthemalignantplasmacells.TheBMnicheiscomposedofacellularcompartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellularmatrix(ECM)andtheliquidmilieu(cytokines,growthfactors,andchemokines).Inthispaperwediscusshowthe interactionbetweenthemalignantplasmacellandtheBMmicroenvironmentallowedmyelomaprogressionthroughcellhoming andthenewconceptofpremetastaticniche. 1.Introduction marrow microenvironment [6]. Substantial advances have been made in understanding the biology of MM through the study of the BM microenvironment. Indeed, the BM niche appears to play an important role in di?erentiation, migration,proliferation,survival,anddrugresistanceofthe malignant plasma cells providing the preclinical evidences for targeting MM cells and bone marrow stromal cells (BMSC) as an antitumor strategy in this dis