Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine英文文献资料.docVIP

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Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine英文文献资料.doc

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Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine英文文献资料

JournalofBiomedicineandBiotechnology?2004:5(2004)293–298?PII.S1110724304403106? RESEARCHARTICLE BioavailabilityandBiokineticsofAnthocyanins FromRedGrapeJuiceandRedWine RolandBitsch,1?MichaelNetzel,1ThomasFrank,2GabrieleStrass,1andIrmgardBitsch3 1 InstituteofNutritionalSciences,Friedrich-Schiller-UniversityJena,Dornburgerstrasse29,07743Jena,Germany IMFORMGmbHInternationalClinicalResearch,Birkenweg14,64295Darmstadt,Germany 2 3 InstituteofNutritionalSciences,Justus-Liebig-UniversityGiessen,Wilhelmstrasse20,35392Giessen,Germany Received3March2004;revised24May2004;accepted15June2004 Inacomparativestudy,9healthyvolunteersingestedasingleoraldoseof400mLredgrapejuiceorredwinewithdose-adjusted anthocyanincontent(283.5mgor279.6mg,resp)incrossover.Thecontentofanthocyaninglucosideswasdetectedinplasmaand urinaryexcretion.Additionally,theplasmaticantioxidantactivitywasassessedafterintake.Basedontheplasmacontent,biokinetic criteriaofthesingleanthocyaninswerecalculated,suchasAUC,cmax,tmax,andtheeliminationratet1/2.Theurinaryexcretionoftotal anthocyaninsdi?eredsigni?cantlyandamountedto0.18%(redwine)and0.23%(redgrapejuice)oftheadministereddose.Addi- tionally,theplasmaticantioxidantactivityincreasedtohigherlevelsafterjuiceingestioncomparedtowine.Theintestinalabsorption oftheanthocyaninsofredgrapejuiceseemedtobeimprovedcomparedtoredwine,suggestingapossiblesynergistice?ectofthe glucosecontentofthejuice.Theimprovedabsorptionresultedinanenhancedplasmaticbioactivity. INTRODUCTION single-centerstudyundercontrolledconditions,thevol- unteersingestedafteranovernightfastingasingleportion ofeither400mLredwine(varietyLemberger,Germany) or the same volume of diluted commercially obtained red grape juice concentrate with identical total antho- cyanin doses of 283.5mg (red grape juice) or 279. 6mg (redwine).Thetestphaseswereseparatedbya4-weekin- terval.Eachpersonservedashisorherowncontrol.The orderofthebeverageingestionwasnotrandomized.The wineandthejuicewereingestedtogetherwithwhiterolls and30gofc